Document Detail


The effect of ibogaine on kappa-opioid- and 5-HT3-induced changes in stimulation-evoked dopamine release in vitro from striatum of C57BL/6By mice.
MedLine Citation:
PMID:  7757494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ibogaine is an indole alkaloid that has been suggested to have potential efficacy for interrupting dependency on stimulant drugs. The kappa-opioid and serotonin 5-HT3 systems may be involved in the action of ibogaine, related to their modulation of dopaminergic transmission. The kappa-opioid agonist U 62066 attenuated the in vitro stimulation-evoked efflux of tritium label from striatal tissue prelabeled with [3H]dopamine. In mice pretreated with ibogaine.HCI (40 mg/kg IP given 2 h prior or 2 x 40 mg/kg and animals killed 18 h later), the inhibitory effect of U 62066 on stimulation-evoked release of tritium was eliminated. The 5-HT3 agonist phenylbiguanide had a biphasic effect on stimulation-evoked release of tritium; at 10(-6) M phenylbiguanide, stimulation-evoked release was attenuated. At 10(-5) M the basal outflow of tritium was increased. Ibogaine pretreatment had no effect on basal or stimulation-evoked release in the presence of 10(-6) M phenylbiguanide, but increased the stimulation-evoked outflow of tritium in the presence of 10(-5) M phenylbiguanide. Cocaine (10(-6) M), a dopamine uptake blocker, increased the electrically-evoked release of dopamine; ibogaine pretreatment did not affect the enhanced electrically-induced release of [3H]dopamine by in vitro cocaine. The effects of ibogaine on the kappa-opioid and 5-HT3 receptors, located presynaptically on striatal dopamine terminals, modulating dopamine release may partly underlie its putative antiaddictive properties.
Authors:
H Sershen; A Hashim; A Lajtha
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  36     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1995  
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  587-91     Citation Subset:  IM    
Affiliation:
Nathan S. Kline Institute, Center for Neurochemistry, Orangeburg, NY 10962, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biguanides / pharmacology
Cocaine / pharmacology
Corpus Striatum / drug effects*,  metabolism
Dopamine / metabolism*
Electric Stimulation
Ibogaine / pharmacology*
Male
Mice
Mice, Inbred C57BL
Pyrrolidines / pharmacology
Receptors, Opioid, kappa / drug effects*
Receptors, Serotonin / drug effects*
Chemical
Reg. No./Substance:
0/Biguanides; 0/Pyrrolidines; 0/Receptors, Opioid, kappa; 0/Receptors, Serotonin; 102-02-3/phenyl biguanide; 50-36-2/Cocaine; 83-74-9/Ibogaine; 87151-85-7/spiradoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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