| The effect of hypoxia on photocytotoxicity of TICS tricarbocyanine dye in vitro. | |
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MedLine Citation:
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PMID: 16614714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the effect of cell oxygenation on photocytotoxicity of a novel tricarbocyanine indolenine dye covalently bound to glucose (TICS). METHODS: HeLa cells were incubated with 5 microM TICS, 2 h later irradiated by laser at 740 nm with a light dose of 10 J/cm(2), delivered at a power density of 10, 20, 25 or 30 mW/cm(2), in air or in argon atmosphere, and then scored for viability. RESULTS: The photocytotoxicity of TICS increased dramatically as the power density was reduced. Under hypoxia TICS-photosensitized cell death was determined but its value was lowered, compared to photoirradiation in the air. CONCLUSION: Photosensitizing effect of TICS is only partially dependent on the oxygenation of tumor cells. |
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Authors:
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Y P Istomin; E N Alexandrova; E A Zhavrid; E S Voropay; M P Samtsov; K N Kaplevsky; A P Lugovsky; A A Lugovsky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental oncology Volume: 28 ISSN: 1812-9269 ISO Abbreviation: Exp. Oncol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-14 Completed Date: 2006-05-24 Revised Date: 2010-01-15 |
Medline Journal Info:
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Nlm Unique ID: 101230541 Medline TA: Exp Oncol Country: Ukraine |
Other Details:
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Languages: eng Pagination: 80-2 Citation Subset: IM |
Affiliation:
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NN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus. Istomin@users.med.by |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Hypoxia* Cell Survival / drug effects, radiation effects Hela Cells Humans Kinetics Photochemotherapy / methods |
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