Document Detail

The effect of hypoxia on neurohypophyseal hormone release in fetal and maternal sheep.
MedLine Citation:
PMID:  6422435     Owner:  NLM     Status:  MEDLINE    
The effect of hypoxemia on arginine vasopressin (AVP) and oxytocin (OT) release was investigated in the chronically catheterized fetus and ewe. During 30 min of 10% maternal oxygen delivery, mean (+/- SEM) arterial PO2 decreased from 105 +/- 10.6 to 48 +/- 3.5 mm Hg in the ewe and from 21 +/- 1.3 to 12 +/- 0.8 mm Hg in the fetus (each P less than 0.001). Arterial PCO2 decreased from 35 +/- 4.4 to 29 +/- 1.0 mm Hg in the ewe, whereas fetal PCO2 decreased from 43 +/- 2.3 to 35 +/- 3.5 mm Hg (P less than 0.05). Blood pH increased from 7.44 +/- 0.03 to 7.56 +/- 0.04 in the ewe (P less than 0.01) and from 7.36 +/- 0.004 to 7.40 +/- 0.006 in the fetuses (P less than 0.01). Baseline mean AVP levels were identical in ewes and fetuses (0.7 +/- 0.1 microU/ml). After 30 min of hypoxia, plasma AVP levels remained unchanged in the ewes (0.9 +/- 0.1), but increased dramatically in the fetuses (47 +/- 21 microU/ml) (P less than 0.001). There was a highly significant correlation between the duration of hypoxia and log fetal AVP concentrations (r = 0.85). The log fetal plasma AVP also was inversely correlated to the log fetal PO2 values (r = 0.83). Mean baseline fetal and maternal plasma OT levels were 2.6 +/- 0.5 microU/ml and 2.2 +/- 0.5 microU/ml, respectively. After 30 min of hypoxia fetal and maternal OT values were 2.9 +/- 0.8 microU/ml (not significant).
H Stegner; R D Leake; S M Palmer; G Oakes; D A Fisher
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  18     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-11     Completed Date:  1984-04-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  188-91     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*
Arginine Vasopressin / blood,  secretion*
Carbon Dioxide / blood
Fetal Hypoxia / physiopathology*
Hydrogen-Ion Concentration
Hypercapnia / physiopathology
Maternal-Fetal Exchange
Oxygen / blood
Oxytocin / blood,  secretion*
Pituitary Gland, Posterior / secretion*
Pregnancy Complications / physiopathology*
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 124-38-9/Carbon Dioxide; 50-56-6/Oxytocin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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