| The effect of hypoxemia and exercise on acute mountain sickness symptoms. | |
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MedLine Citation:
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PMID: 23154995 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Performing exercise during the first hours of hypoxic exposure is thought to exacerbate acute mountain sickness (AMS), but whether this is due to increased hypoxemia or other mechanisms associated with exercise remains unclear. In 12 healthy males, AMS symptoms were assessed during three 11-h experimental sessions: i) in Hypoxia-exercise, inspiratory O(2) fraction (FiO(2)) was 0.12 and subjects performed 4 h cycling at 45% FiO(2)-specific maximal power output from the 4(th) to the 8(th) hour; ii) in Hypoxia-rest, FiO(2) was continuously adjusted to match the same arterial oxygen saturation as in Hypoxia-exercise and subjects remained at rest; iii) in Normoxia-exercise, FiO(2) was 0.21 and subjects cycled as in Hypoxia-exercise at 45% FiO(2)-specific maximal power output. AMS scores did not differ significantly between Hypoxia-exercise and Hypoxia-rest, while they were significantly lower in Normoxia-exercise (Lake Louise score: 5.5±2.1, 4.4±2.4, 2.3±1.5 and cerebral Environmental Symptom Questionnaire: 1.2±0.7, 1.0±1.0, 0.3±0.4, in Hypoxia-exercise, Hypoxia-rest and Normoxia-exercise, respectively; P<0.01). Headache scored by visual analogue scale was higher in Hypoxia-exercise and Hypoxia-rest compared to Normoxia-exercise (36±22, 35±25, 5±6, P<0.001) while the perception of fatigue was higher in Hypoxia-exercise compared to Hypoxia-rest (60±24, 32±22, 46±23 in Hypoxia-exercise, Hypoxia-rest and Normoxia-exercise, respectively; P<0.01). Despite significant physiological stress during hypoxic exercise and some AMS symptoms induced by normoxic cycling at similar relative workload, exercise does not significantly worsen AMS severity during the first hours of hypoxic exposure at a given arterial oxygen desaturation. Hypoxemia per se appears therefore to be the main mechanism underlying AMS, whether or not exercise is performed. |
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Authors:
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Thomas Rupp; Marc Jubeau; Guillaume Y Millet; Stephane Perrey; François Esteve; Bernard Wuyam; Patrick Levy; Samuel Verges |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-15 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Joseph Fourier University, CHU Grenoble. |
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