Document Detail


The effect of hypoxemia and exercise on acute mountain sickness symptoms.
MedLine Citation:
PMID:  23154995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Performing exercise during the first hours of hypoxic exposure is thought to exacerbate acute mountain sickness (AMS), but whether this is due to increased hypoxemia or other mechanisms associated with exercise remains unclear. In 12 healthy men, AMS symptoms were assessed during three 11-h experimental sessions: 1) in Hypoxia-exercise, inspiratory O(2) fraction (Fi(O(2))) was 0.12, and subjects performed 4-h cycling at 45% Fi(O(2))-specific maximal power output from the 4th to the 8th hour; 2) in Hypoxia-rest, Fi(O(2)) was continuously adjusted to match the same arterial oxygen saturation as in Hypoxia-exercise, and subjects remained at rest; and 3) in Normoxia-exercise, Fi(O(2)) was 0.21, and subjects cycled as in Hypoxia-exercise at 45% Fi(O(2))-specific maximal power output. AMS scores did not differ significantly between Hypoxia-exercise and Hypoxia-rest, while they were significantly lower in Normoxia-exercise (Lake Louise score: 5.5 ± 2.1, 4.4 ± 2.4, and 2.3 ± 1.5, and cerebral Environmental Symptom Questionnaire: 1.2 ± 0.7, 1.0 ± 1.0, and 0.3 ± 0.4, in Hypoxia-exercise, Hypoxia-rest, and Normoxia-exercise, respectively; P < 0.01). Headache scored by visual analog scale was higher in Hypoxia-exercise and Hypoxia-rest compared with Normoxia-exercise (36 ± 22, 35 ± 25, and 5 ± 6, P < 0.001), while the perception of fatigue was higher in Hypoxia-exercise compared with Hypoxia-rest (60 ± 24, 32 ± 22, and 46 ± 23, in Hypoxia-exercise, Hypoxia-rest, and Normoxia-exercise, respectively; P < 0.01). Despite significant physiological stress during hypoxic exercise and some AMS symptoms induced by normoxic cycling at similar relative workload, exercise does not significantly worsen AMS severity during the first hours of hypoxic exposure at a given arterial oxygen desaturation. Hypoxemia per se appears, therefore, to be the main mechanism underlying AMS, whether or not exercise is performed.
Authors:
Thomas Rupp; Marc Jubeau; Guillaume Y Millet; Stéphane Perrey; François Esteve; Bernard Wuyam; Patrick Levy; Samuel Verges
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  114     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-08-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Affiliation:
INSERM U1042, Grenoble, France.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Altitude Sickness / physiopathology*
Anoxia / physiopathology*
Exercise / physiology*
Fatigue / epidemiology,  physiopathology
Humans
Incidence
Male
Rest / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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