Document Detail

The effect of hypovolemic shock on pancreatic secretion.
MedLine Citation:
PMID:  2445870     Owner:  NLM     Status:  MEDLINE    
A vascular pathogenesis of pancreatitis has been postulated in diabetics, the aged, Ortner's Syndrome, and various low-flow states. This report studies canine pancreatic secretion in a preparation of hypovolemic shock produced by controlled hemorrhage maintained for varying durations. Pancreatic secretion was collected by cannulation of the main pancreatic duct in anesthetized dogs. Secretin was administered by continuous intravenous (i.v.) infusion of 4 U/kg/h. Four 15-min samples of pancreatic juice were collected. Then the dogs were bled by arterial line withdrawing 25-30% of total blood volume or until the mean blood pressure dropped to about 60 mmHg. Blood was collected in heparinized containers for reinfusion. Blood samples for amylase and 15-min samples of pancreatic juice for volume, bicarbonate, and enzymes were obtained during hypovolemia as well as during and following restoration of the blood volume. Hypovolemia induced significant decreases in pancreatic flow, bicarbonate and amylase secretion, parameters which increased after reinfusion but never returned to pre-shock levels. Increasing the period of hypovolemia increased the inhibition of pancreatic flow, increased blood amylase elevation, and resulted in visible pancreatic edema. We conclude that pancreatic secretion is diminished by hypovolemia, that this is initially reversible when hypovolemia is brief, but that the disturbance of function progresses to inflammatory pathology when hypovolemia is prolonged.
A Barzilai; J A Medina; L Toth; D A Dreiling
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  1     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1988-01-06     Completed Date:  1988-01-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  IM    
Pancreatic Research Laboratory, Mount Sinai School of Medicine, CUNY, NY 10029.
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MeSH Terms
Amylases / blood
Bicarbonates / secretion
Pancreas / secretion*
Pancreatic Juice / secretion
Proteins / secretion
Shock / metabolism*
Reg. No./Substance:
0/Bicarbonates; 0/Proteins; EC 3.2.1.-/Amylases

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