Document Detail


The effect of hypopnea on low-pressure pulmonary edema.
MedLine Citation:
PMID:  2382895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the mechanical factors involved in ventilation on pulmonary edema are only partially understood. To clarify the effect of ventilation on the adult respiratory distress syndrome (ARDS), we examined the effect of reducing rate and tidal volume on oleic acid-induced low-pressure pulmonary edema in dogs, hypothesizing that hypopnea would reduce lung edema. We placed the experimental animals on venous-venous extracorporeal membrane oxygenation (ECMO) for CO2 clearance and oxygenation 1 h after the injury. This allowed reduction of the ventilatory rate from 17.2 +/- 4.8 to 3.3 +/- 0.8 breaths/min and tidal volume from 20 to 16 ml/kg, effectively resting the injured lung. After 5 h of hypopnea there was no reduction in edema by gravimetric or extravascular thermal volume measurements. The ECMO-facilitated hypopnea reduced airway pressure and pulmonary artery pressure while improving arterial oxygen saturation but increased venous admixture. These results suggest that there may be a supportive role for ECMO-assisted hypopnea, but there was no direct beneficial effect of hypopnea on edema.
Authors:
J Yanos; K Presberg; G Crawford; J Meller; L D Wood; J I Sznajder
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  142     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-11     Completed Date:  1990-09-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  316-20     Citation Subset:  AIM; IM    
Affiliation:
University of Pittsburgh, Montefiore Hospital, Pennsylvania 15213.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Extracorporeal Membrane Oxygenation*
Male
Oleic Acid
Oleic Acids / toxicity
Pulmonary Edema / chemically induced,  therapy*
Respiration / physiology
Respiration, Artificial / methods
Respiratory Distress Syndrome, Adult / therapy
Tidal Volume
Grant Support
ID/Acronym/Agency:
HL-07484/HL/NHLBI NIH HHS; HL-30835/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Oleic Acids; 112-80-1/Oleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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