| The effect of hypokinesia and hypodynamia on protein turnover and the growth of four skeletal muscles of the rat. | |
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MedLine Citation:
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PMID: 3763379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An animal suspension model has been used to simulate the weightlessness experienced during space travel. This procedure results in a reduction in the normal shortening (i.e. hypokinesia) and force generation functions of hind limb muscles (i.e. hypodynamia). The ensuing muscle atrophy was studied over 12 days in different muscle types. Slow muscles (e.g. the soleus) underwent a more pronounced atrophy than intermediate (i.e. gastrocnemius) and fast phasic muscles (e.g. extensor digitorum longus). In all muscle types inactivity resulted in a smaller accumulation of DNA and losses of RNA and protein after 5 days. The latter arose from a decrease in the rate of protein synthesis (measured in vivo) and an increase in protein breakdown. Increased specific activities of cathepsins B and D also supported the view that there is an increased proteolysis after hypokinesia and hypodynamia. When the inactive soleus was simultaneously held in a lengthened (stretched) state the atrophy was prevented through a large increase in the fractional rate of protein synthesis. Protein degradation remained elevated with stretch, thereby slowing the growth of these muscles relative to those in pair-fed, ambulatory controls. The much smaller atrophy of the tibialis anterior and extensor digitorum longus muscles in suspended only limbs represented an underestimate of the true atrophic effects of hypokinesia and hypodynamia. In this model gravity pulls the suspended foot into a plantar flexed position, thereby permanently stretching and protecting such flexor muscles. When this influence of stretch was removed a greater atrophy ensued, mainly due to the loss of the stretch-induced stimulation of protein synthesis.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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D F Goldspink; A J Morton; P Loughna; G Goldspink |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 407 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-11-13 Completed Date: 1986-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 333-40 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Immobilization* Male Muscle Development Muscle Proteins / metabolism* Muscles / pathology, physiology* Muscular Atrophy / etiology, pathology, prevention & control Posture Rats Rats, Inbred Strains Weightlessness* |
| Chemical | |
Reg. No./Substance:
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0/Muscle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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