Document Detail

The effect of hypnosis on systemic and rectal mucosal measures of inflammation in ulcerative colitis.
MedLine Citation:
PMID:  18510607     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Hypnotherapy is effective in several diseases with a psychosomatic component. Our aim was to study the effects of one session of hypnosis on the systemic and rectal mucosal inflammatory responses in patients with active ulcerative colitis (UC). METHODS: In total, 17 patients with active UC underwent a 50-min session of gut-focused hypnotherapy. Before and after each procedure, the systemic inflammatory response was assessed by serum interleukin (IL)-6 and IL-13 concentrations, tumor necrosis factor-alpha (TNF-alpha) and IL-6 production by lipopolysaccharide (LPS)-stimulated whole blood, leukocyte count, natural killer (NK) cell number, platelet activation, and platelet-leukocyte aggregate formation. Rectal inflammation was assessed by mucosal release of substance P (SP), histamine, IL-13 and TNF-alpha, reactive oxygen metabolite production, and mucosal blood flow. Eight patients with active UC underwent a control procedure. RESULTS: Hypnosis decreased pulse by a median 7 beats per minute (bpm) (P= 0.0008); it also reduced the median serum IL-6 concentration by 53% (P= 0.001), but had no effect on the other systemic variables assessed. Hypnosis reduced rectal mucosal release of SP by a median 81% (P= 0.001), histamine by 35% (P= 0.002) and IL-13 by 53% (P= 0.003), and also, blood flow by 18% (P= 0.0004). The control protocol had no effect on any of the variables assessed. CONCLUSIONS: Hypnosis reduced several components of the systemic and mucosal inflammatory response in active ulcerative colitis toward levels found previously in the inactive disease. Some of these effects may contribute to the anecdotally reported benefits of hypnotherapy and provide a rationale for controlled trials of hypnotherapy in UC.
Joel E Mawdsley; David G Jenkins; Marion G Macey; Louise Langmead; David S Rampton
Related Documents :
10909887 - Gastric-arterial pco2 gradient does not reflect systemic and splanchnic hemodynamics or...
1568587 - Gallbladder mucosal blood flow increases during early cholesterol gallstone formation.
8179007 - Osmotic water flow pathways across necturus gallbladder: role of the tight junction.
9049737 - Esophageal pco2 as a monitor of perfusion failure during hemorrhagic shock.
20477767 - Polymorphisms of alcohol dehydrogenase-1b and aldehyde dehydrogenase-2 and the blood an...
15185577 - A sero-epidemiological survey of blood parasites in cattle in the north-eastern free st...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-05-28
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  103     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-12     Completed Date:  2008-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1460-9     Citation Subset:  IM    
Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London, Queen Mary School of Medicine and Dentistry, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Colitis, Ulcerative / metabolism,  pathology,  therapy*
Cytokines / metabolism*
Inflammation Mediators / metabolism*
Intestinal Mucosa / blood supply,  metabolism,  pathology
Middle Aged
Rectum / blood supply,  metabolism,  pathology
Regional Blood Flow / physiology
Treatment Outcome
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A comparison of endoscopic treatment and surgery in early esophageal cancer: an analysis of surveill...
Next Document:  Minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction.