| The effect of hyperthermia on ornithine decarboxylase activity in different rat tissues. | |
| | |
MedLine Citation:
|
PMID: 3337747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperthermia produced a decrease of ornithine decarboxylase activity in different tissues of adult rats. The fall in ornithine decarboxylase was dependent on time of exposure and temperature. The decay of ornithine decarboxylase activity in liver, brain, kidney, heart, spleen and testes was rather similar. The t1/2 for liver ornithine decarboxylase determined by the hyperthermic treatment (40 degrees ambient temperature) was 20 min. Ornithine decarboxylase activity was recovered in all tissues exposed to the hyperthermic shock after a period of 4 hours, although the degree of recovery was dependent on the type of tissue. The effect that hyperthermia produces on ornithine decarboxylase activity in rats could be related to an inhibition in the synthesis of active enzyme rather than to a specific degradation or inactivation of ornithine decarboxylase molecule. |
| | |
Authors:
|
R Peñafiel; F Solano; A Cremades |
Related Documents
:
|
17457 - Preenrichment procedure for detection of salmonella in gelatin. 7424597 - Response variations of neurons in the lateral geniculate body of the freely moving rat. 7892117 - Changes in hypothalamic temperature of rats after daily exposure to heat at a fixed time. 11086667 - Increases in body mass of rats during spaceflight: models and measurements. 8169817 - Fischer and lewis rat strains show differential cocaine effects in conditioned place pr... 3371477 - Alpha 2 interferon in the prevention of n-nitroso-methyl urea induced breast cancer in ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochemical pharmacology Volume: 37 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1988 Feb |
Date Detail:
|
Created Date: 1988-02-25 Completed Date: 1988-02-25 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 497-502 Citation Subset: IM |
Affiliation:
|
Departmentos de Bioquímica y Farmacología, Facultad de Medicina, Universidad de Murcia, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
metabolism Animals Cycloheximide / pharmacology Enzyme Induction Enzyme Stability Hot Temperature Hyperthermia, Induced* Liver / drug effects, enzymology* Male Organ Specificity Ornithine Decarboxylase / biosynthesis, metabolism* Rats Rats, Inbred Strains Thioacetamide / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 62-55-5/Thioacetamide; 66-81-9/Cycloheximide; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of nonprotein thiols in enzymatic reduction of 2-nitroimidazoles.
Next Document: Felodipine-induced inhibition of polymorphonuclear leukocyte functions.