Document Detail

The effect of hypertension on the apparent diffusion coefficient values of kidneys.
MedLine Citation:
PMID:  18306138     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to diagnose hypertension- induced renal microvascular dysfunction using renal diffusion magnetic resonance imaging (MRI) and to identify any correlation between blood pressure level and apparent diffusion coefficient (ADC) values. MATERIALS AND METHODS: The study included 77 consecutive patients (41 women and 36 men). The patients were divided into 4 groups according to their blood pressure level. Group 1 consisted of normotensive control patients; group 2, pre-hypertensive patients; group 3, stage 1 hypertensive patients; and group 4, stage 2 hypertensive patients. All patients underwent transverse diffusion-weighted multi-section echo-planar MRI. In the transverse ADC maps, rectangular regions of interest were placed in the cortex at 3 sites (upper, middle, and lower pole) of each kidney. The ADCs of the kidneys were calculated separately for low, average, and high b values to enable the differentiation of the relative influence of the perfusion fraction and true diffusion. In addition, a multi-slab balanced turbo field-echo magnetic resonance angiographic technique (without the use of a contrast agent) was used to exclude renal artery stenosis. RESULTS: There was no statistically significant difference between the groups in age, and no significant correlation between the ADC values of both kidneys and blood pressure level in each group (P > 0.05). In addition, the ADC values of patients with microalbuminuria did not differ from those of the other patients (P > 0.05). CONCLUSION Despite the end-organ damage caused by hypertension, renal microvascular functions were preserved and hypertension did not affect ADC values.
Erkan Yildirim; Hakan Güllü; Mustafa Calişkan; Elif Karadeli; Ismail Kirbaş; Haldun Müderrisoğlu
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Diagnostic and interventional radiology (Ankara, Turkey)     Volume:  14     ISSN:  1305-3825     ISO Abbreviation:  -     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241152     Medline TA:  Diagn Interv Radiol     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
Department of Radiology, Başkent University School of Medicine, Ankara, Turkey.
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MeSH Terms
Case-Control Studies
Diffusion Magnetic Resonance Imaging*
Hypertension / complications*
Kidney / blood supply*
Kidney Diseases / etiology,  pathology,  physiopathology*
Middle Aged
Predictive Value of Tests
Renal Circulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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