Document Detail

The effect of the 'hypertensinogenic' steroid, 9 alpha-fluorocortisol on blood pressure in sheep with ACTH-induced hypertension.
MedLine Citation:
PMID:  3011328     Owner:  NLM     Status:  MEDLINE    
The effect of treatment with 9 alpha-fluorocortisol (9 alpha FF), a steroid which causes hypertension in sheep, was examined in sheep with ACTH-induced hypertension. ACTH treatment alone increased mean arterial pressure (MAP), plasma Na concentration, water intake and urine volume and decreased plasma K concentration. 9 alpha FF treatment, for 3 days during continuing ACTH administration, did not change blood pressure but increased heart rate, water intake and urine volume and decreased urinary K excretion. As 9 alpha FF did not cause a further increment in blood pressure in sheep with ACTH-induced hypertension it is possible that both ACTH and 9 alpha FF may produce hypertension by similar mechanisms.
E H Mills; J P Coghlan; D A Denton; M A Nelson; C D Spence; J A Whitworth; B A Scoggins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  12     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-07-24     Completed Date:  1986-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  587-91     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / pharmacology*
Blood Pressure / drug effects*
Cortisone / analogs & derivatives*,  pharmacology
Heart Rate / drug effects
Hypertension / chemically induced,  physiopathology*
Potassium / blood,  urine
Sodium / blood,  urine
Time Factors
Reg. No./Substance:
53-06-5/Cortisone; 7440-09-7/Potassium; 7440-23-5/Sodium; 79-60-7/9-fluorocortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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