| The effect of the 'hypertensinogenic' steroid, 9 alpha-fluorocortisol on blood pressure in sheep with ACTH-induced hypertension. | |
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MedLine Citation:
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PMID: 3011328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of treatment with 9 alpha-fluorocortisol (9 alpha FF), a steroid which causes hypertension in sheep, was examined in sheep with ACTH-induced hypertension. ACTH treatment alone increased mean arterial pressure (MAP), plasma Na concentration, water intake and urine volume and decreased plasma K concentration. 9 alpha FF treatment, for 3 days during continuing ACTH administration, did not change blood pressure but increased heart rate, water intake and urine volume and decreased urinary K excretion. As 9 alpha FF did not cause a further increment in blood pressure in sheep with ACTH-induced hypertension it is possible that both ACTH and 9 alpha FF may produce hypertension by similar mechanisms. |
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Authors:
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E H Mills; J P Coghlan; D A Denton; M A Nelson; C D Spence; J A Whitworth; B A Scoggins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 12 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1985 Nov-Dec |
Date Detail:
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Created Date: 1986-07-24 Completed Date: 1986-07-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 587-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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pharmacology* Animals Blood Pressure / drug effects* Cortisone / analogs & derivatives*, pharmacology Drinking Female Heart Rate / drug effects Hypertension / chemically induced, physiopathology* Potassium / blood, urine Sheep Sodium / blood, urine Time Factors |
| Chemical | |
Reg. No./Substance:
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53-06-5/Cortisone; 7440-09-7/Potassium; 7440-23-5/Sodium; 79-60-7/9-fluorocortisone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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