| The effect of hyperbaric oxygen and air on cartilage tissue engineering. | |
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MedLine Citation:
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PMID: 23154337 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT: There is an urgent need to develop tissue-engineered cartilage for patients experiencing joint malfunction due to insufficient self-repairing capacity of articular cartilage. The aim of this research was to explore the effect of hyperbaric oxygen and air on tissue-engineered cartilage formation from human adipose-derived stem cells seeding on the gelatin/polycaprolactone biocomposites. The results of histological analyses indicate that under hyperbaric oxygen and air stimulation, the cell number of chondrocytes in cartilage matrix was not significantly increased, but the 1,9-dimethylmethylene blue assay showed that the glycosaminoglycans syntheses markedly increased compared to the control group. In quantification real-time polymerase chain reaction results, the chondrogenic-specific gene expression of SOX9, aggrecan, and COL2A1 were compared respectively. Within the limitation of this study, it was concluded that 2.5 atmosphere absolute oxygen and air may provide a stress environment to help cartilage tissue engineering development. |
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Authors:
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Juin-Hong Cherng; Shun-Cheng Chang; Shyi-Gen Chen; Ming-Lun Hsu; Po-Da Hong; Shou-Chen Teng; Yi-Hsin Chan; Chih-Hsin Wang; Tim-Mo Chen; Niann-Tzyy Dai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of plastic surgery Volume: 69 ISSN: 1536-3708 ISO Abbreviation: Ann Plast Surg Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805336 Medline TA: Ann Plast Surg Country: United States |
Other Details:
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Languages: eng Pagination: 650-5 Citation Subset: IM |
Affiliation:
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From the *Department of Dentistry, National Yang-Ming University; †Department of Plastic and Reconstructive Surgery, Tri-Service General Hospital; and ‡Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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