Document Detail

The effect of hyperbaric oxygen and air on cartilage tissue engineering.
MedLine Citation:
PMID:  23154337     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: There is an urgent need to develop tissue-engineered cartilage for patients experiencing joint malfunction due to insufficient self-repairing capacity of articular cartilage. The aim of this research was to explore the effect of hyperbaric oxygen and air on tissue-engineered cartilage formation from human adipose-derived stem cells seeding on the gelatin/polycaprolactone biocomposites. The results of histological analyses indicate that under hyperbaric oxygen and air stimulation, the cell number of chondrocytes in cartilage matrix was not significantly increased, but the 1,9-dimethylmethylene blue assay showed that the glycosaminoglycans syntheses markedly increased compared to the control group. In quantification real-time polymerase chain reaction results, the chondrogenic-specific gene expression of SOX9, aggrecan, and COL2A1 were compared respectively. Within the limitation of this study, it was concluded that 2.5 atmosphere absolute oxygen and air may provide a stress environment to help cartilage tissue engineering development.
Juin-Hong Cherng; Shun-Cheng Chang; Shyi-Gen Chen; Ming-Lun Hsu; Po-Da Hong; Shou-Chen Teng; Yi-Hsin Chan; Chih-Hsin Wang; Tim-Mo Chen; Niann-Tzyy Dai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  69     ISSN:  1536-3708     ISO Abbreviation:  Ann Plast Surg     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  650-5     Citation Subset:  IM    
From the *Department of Dentistry, National Yang-Ming University; †Department of Plastic and Reconstructive Surgery, Tri-Service General Hospital; and ‡Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, Republic of China.
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