Document Detail


The effect of hydroxyurea on hemoglobin F in patients with myeloproliferative syndromes.
MedLine Citation:
PMID:  2410068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal hemoglobin (Hb F) may increase in patients receiving chemotherapeutic drugs, a result of potential use in patients with symptomatic hemoglobinopathies. We examined Hb F in 13 patients with myeloproliferative disease (six polycythemia vera, five polycythemia vera with myeloid metaplasia, one agnogenic myeloid metaplasia, and one chronic myelogenous leukemia) who were treated with hydroxyurea. Four patients showed an increase in Hb F from less than 1% to between 5% and greater than 8% while on hydroxyurea, and a decline to less than 1% when the drug was discontinued. This group of "responders" received a higher average daily dose of hydroxyurea, which was administered continuously rather than intermittently, when compared to the "nonresponders." Mean corpuscular volumes (MCVs) rose in most patients, and i antigen remained elevated or decreased; neither parameter correlated with Hb F levels. Both responders and nonresponders had therapeutically desirable suppression of WBCs and platelets, and almost all had no depression of reticulocytes or Hb.
Authors:
B P Alter; H S Gilbert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  66     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-11     Completed Date:  1985-09-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Erythrocyte Indices
Female
Fetal Hemoglobin / analysis*
Humans
Hydroxyurea / therapeutic use*
Male
Middle Aged
Myeloproliferative Disorders / blood,  drug therapy*
Polycythemia Vera / drug therapy
Primary Myelofibrosis / drug therapy
Grant Support
ID/Acronym/Agency:
CA31656/CA/NCI NIH HHS; HL26132/HL/NHLBI NIH HHS; RR71/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
127-07-1/Hydroxyurea; 9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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