| The effect of hydroxyurea on hemoglobin F in patients with myeloproliferative syndromes. | |
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MedLine Citation:
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PMID: 2410068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal hemoglobin (Hb F) may increase in patients receiving chemotherapeutic drugs, a result of potential use in patients with symptomatic hemoglobinopathies. We examined Hb F in 13 patients with myeloproliferative disease (six polycythemia vera, five polycythemia vera with myeloid metaplasia, one agnogenic myeloid metaplasia, and one chronic myelogenous leukemia) who were treated with hydroxyurea. Four patients showed an increase in Hb F from less than 1% to between 5% and greater than 8% while on hydroxyurea, and a decline to less than 1% when the drug was discontinued. This group of "responders" received a higher average daily dose of hydroxyurea, which was administered continuously rather than intermittently, when compared to the "nonresponders." Mean corpuscular volumes (MCVs) rose in most patients, and i antigen remained elevated or decreased; neither parameter correlated with Hb F levels. Both responders and nonresponders had therapeutically desirable suppression of WBCs and platelets, and almost all had no depression of reticulocytes or Hb. |
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Authors:
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B P Alter; H S Gilbert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood Volume: 66 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-09-11 Completed Date: 1985-09-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 373-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Erythrocyte Indices Female Fetal Hemoglobin / analysis* Humans Hydroxyurea / therapeutic use* Male Middle Aged Myeloproliferative Disorders / blood, drug therapy* Polycythemia Vera / drug therapy Primary Myelofibrosis / drug therapy |
| Grant Support | |
ID/Acronym/Agency:
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CA31656/CA/NCI NIH HHS; HL26132/HL/NHLBI NIH HHS; RR71/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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127-07-1/Hydroxyurea; 9034-63-3/Fetal Hemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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