Document Detail

The effect of hydrogel injection on cardiac function and myocardial mechanics in a computational post-infarction model.
MedLine Citation:
PMID:  22439799     Owner:  NLM     Status:  Publisher    
An emerging therapy to limit adverse heart remodelling following myocardial infarction (MI) is the injection of polymers into the infarcted left ventricle (LV). In the few numerical studies carried out in this field, the definition and distribution of the hydrogel in the infarcted myocardium were simplified. In this computational study, a more realistic biomaterial distribution was simulated after which the effect on cardiac function and mechanics was studied. A validated finite element heart model was used in which an antero-apical infarct was defined. Four infarct models were created representing different temporal phases in the progression of a MI. Hydrogel layers were simulated in the infarcted myocardium in each model. Biomechanical and functional improvement of the LV was found after hydrogel inclusion in the ischaemic models representing the early phases of MI. In contrast, only functional but no mechanical restitution was shown in the scar model due to hydrogel presence.
Jeroen Kortsmit; Neil H Davies; Renee Miller; Jesse R Macadangdang; Peter Zilla; Thomas Franz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-22
Journal Detail:
Title:  Computer methods in biomechanics and biomedical engineering     Volume:  -     ISSN:  1476-8259     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802899     Medline TA:  Comput Methods Biomech Biomed Engin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town , Cape Town , South Africa.
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