| The effect of hydrocortisone and 6-methylprednisolone on the cytoplasmic membrane of rat thymocytes in an vitro system | |
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MedLine Citation:
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PMID: 307499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hydrocortisone and 6-methylprednisolone increase the binding constant of anilinenaphthalene-sulphonate (ANS) with the cytoplasmatic thymocytes membrane following a 2--3 hour long incubation in vitro. Over the same period these compounds stimulate the liberation of potassium ions from the thymocytes. A supravital staining of the thymocytes with Trypan blue did not change during the whole time of the hormones action. The effect of the hydrocortisone and 6-methylprednisolone action on the ANS binding constant and potassium release depende upon the duration of incubation and concentration of the steriod in the medium. Hydrocortisone produces a greater influence than does 6-methylprednisolone. |
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Authors:
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R D Seifulla; S A Burov; A N Zakharov; E A Sychev; A V Chubarova |
Publication Detail:
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Type: English Abstract; In Vitro; Journal Article |
Journal Detail:
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Title: Farmakologiia i toksikologiia Volume: 41 ISSN: 0014-8318 ISO Abbreviation: Farmakol Toksikol Publication Date: 1978 Jun-Aug |
Date Detail:
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Created Date: 1978-09-25 Completed Date: 1978-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 16920420R Medline TA: Farmakol Toksikol Country: USSR |
Other Details:
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Languages: rus Pagination: 469-73 Citation Subset: IM |
Vernacular Title:
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Vliianie gidrokortizona i 6-metilprednizolona na tsitoplazmaticheskuiu membrany timotsitov krys v opytakh in vitro. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anilino Naphthalenesulfonates
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metabolism Animals Cytoplasm / drug effects, metabolism, ultrastructure Hydrocortisone / pharmacology* Membranes / drug effects, metabolism Methylprednisolone / pharmacology* Potassium / metabolism Rats T-Lymphocytes / drug effects*, metabolism, ultrastructure Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anilino Naphthalenesulfonates; 50-23-7/Hydrocortisone; 7440-09-7/Potassium; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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