| The effect of human immunodeficiency virus-1 on monocyte-derived dendritic cell maturation and function. | |
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MedLine Citation:
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PMID: 22943206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells (DC) are mediators of the adaptive immune response responsible for antigen presentation to naive T cells in secondary lymph organs. Human immunodeficiency virus (HIV-1) has been reported to inhibit the maturation of DC, but a clear link between maturation and function has not been elucidated. To understand further the effects of HIV-1 on DC maturation and function, we expanded upon previous investigations and assessed the effects of HIV-1 infection on the expression of surface molecules, carbohydrate endocytosis, antigen presentation and lipopolysaccharide (LPS) responsiveness over the course of maturation. In vitro infection with HIV-1 resulted in an increase in the expression of DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) as well as decreases in maturation-induced CCR7 and major histocompatibility complex (MHC)-II expression. Retention of endocytosis that normally occurs with DC maturation as well as inhibition of antigen presentation to CD8(+) T cells was also observed. Mitogen-activated protein kinase (MAPK) responsiveness to LPS as measured by phosphorylation of p38, c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK)1/2 was not affected by HIV-1 infection. In summary, in-vitro HIV-1 impairs DC maturation, as defined by cell surface protein expression, with selective alterations in mature DC function. Understanding the mechanisms of DC dysfunction in HIV infection will provide further insight into HIV immune pathogenesis. |
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Authors:
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P Fairman; J B Angel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 170 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-04 Completed Date: 2012-11-16 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 101-13 Citation Subset: IM |
Copyright Information:
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© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. |
Affiliation:
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The Ottawa Hospital Research Institute, Ottawa, ON, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism Cell Adhesion Molecules / metabolism Cell Proliferation Cells, Cultured Dendritic Cells / immunology*, virology Endocytosis / immunology Genes, MHC Class II HIV-1 / immunology* Humans JNK Mitogen-Activated Protein Kinases / immunology, metabolism Lectins, C-Type / metabolism Lipopolysaccharides / immunology, pharmacology Mitogen-Activated Protein Kinases / immunology, metabolism Monocytes / immunology, virology Phosphorylation Polymerase Chain Reaction Receptors, CCR7 / metabolism Receptors, Cell Surface / metabolism* T-Lymphocytes / immunology*, metabolism p38 Mitogen-Activated Protein Kinases / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HOP-98830//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CCR7 protein, human; 0/Cell Adhesion Molecules; 0/DC-specific ICAM-3 grabbing nonintegrin; 0/Lectins, C-Type; 0/Lipopolysaccharides; 0/Receptors, CCR7; 0/Receptors, Cell Surface; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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