Document Detail

The effect of hormone replacement therapy on metabolism of lipoprotein remnants in postmenopausal women.
MedLine Citation:
PMID:  10687885     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The measurement of remnant-like particles reflects chylomicron and very low density lipoprotein remnants which are most likely atherogenic particles. We investigated the effects of menopausal status and postmenopausal hormone replacement on metabolism of remnant lipoprotein-cholesterol. METHODS: We measured remnant lipoprotein-cholesterol by an immunoseparation assay in 20 premenopausal, 40 postmenopausal, and 30 bilaterally oophorectomized women. Of 70 postmenopausal subjects, 21 surgically menopausal women (with total hysterectomy) were started on hormone replacement with conjugated equine estrogen, 0.625 mg/day, and 36 naturally postmenopausal women were begun on a combination of conjugated equine estrogen 0.625 mg/day, plus medroxyprogesterone acetate, 2.5 mg/day. Plasma levels of remnant lipoprotein-cholesterol and other common lipids were measured after 6 and 12 months of treatment. RESULTS: Plasma remnant lipoprotein-cholesterol levels in postmenopausal and surgically menopausal women were significantly higher than in premenopausal women (P < 0.005). Plasma total and low-density lipoprotein cholesterol levels decreased and high-density lipoprotein cholesterol increased significantly (P < 0.01) in both treatment groups, respectively. Plasma triglyceride levels were not changed by treatment; however, remnant lipoprotein-cholesterol levels decreased in both treatment groups (estrogen group; P = 0.07, estrogen-progestin group; P < 0.05). No side effects of therapy were consistently reported. CONCLUSIONS: We confirmed that remnant lipoprotein-cholesterol increases after menopause. Hormone replacement therapy improves disordered lipoprotein metabolism and exerts a favorable effect on lipoprotein remnant metabolism in postmenopausal women.
M Sanada; H Nakagawa; I Kodama; T Sakasita; K Ohama
Related Documents :
10367605 - Relations of trait depression and anxiety to low lipid and lipoprotein concentrations i...
2318345 - Effects of omega-3 fish oils on plasma lipids, lipoprotein composition, and postheparin...
163935 - Characteristics of serum lipid and lipoprotein patterns in patients with coronary scler...
12422985 - Superiority of traditional village diet and lifestyle in minimizing cardiovascular dise...
23658335 - Impact of source of sulfur on ruminal hydrogen sulfide and logic for the ruminal availa...
8118475 - Energy cost of arousal: effect of sex, race and obesity.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Maturitas     Volume:  34     ISSN:  0378-5122     ISO Abbreviation:  Maturitas     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-05-04     Completed Date:  2000-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Hiroshima University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Arteriosclerosis / prevention & control
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Hormone Replacement Therapy*
Middle Aged
Postmenopause / blood*
Triglycerides / blood*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterization of hot flashes reported by healthy postmenopausal women receiving raloxifene or pla...
Next Document:  Effects of combined sex hormone replacement therapy on small artery biomechanics in pharmacologicall...