Document Detail

The effect of hormone replacement therapy on endothelial function in postmenopausal women with hypertension.
MedLine Citation:
PMID:  14737044     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelial dysfunction has been implicated in the pathophysiology of cardiovascular diseases, including arterial hypertension. The present study was undertaken to assess endothelial function in postmenopausal women with arterial hypertension receiving hormone replacement therapy and antihypertensive treatment. MATERIAL/METHODS: A group of 76 women with natural menopause and essential mild to moderate arterial hypertension entered the study. Forty women received a transdermal, combined hormone replacement therapy (HRT) of 17 -estradiol and norethisterone acetate, whereas 36 served as controls. At baseline and at 3 and 12 months, all patients underwent 24-hr blood pressure monitoring and an exercise test, before which, at peak exercise, and after a 15-min recovery period venous blood was drawn to measure the level of nitrite/nitrate (NOx) according to the Griess RESULTS: At 3 and 12 months after beginning HRT, the level of NOx at rest was slightly increased, with marked individual differences in response to HRT. In women not receiving HRT, NOx did not change. In the HRT group, 52.5% at 3 months and 47.5% at 12 months had significantly increased levels compared with the baseline values (17.8+/-6.7 vs. 32.8+/-4.5 vs. 28.7+/-1.1 Kmol/l; p=0.002). The increased NOx level in responders was associated with decreased LDL cholesterol (3.62+/-1.2 vs. 3.53+/-1.3 vs. 2.6+/-0.6 mmol/l; p=0.01). At 12 months, blood pressure values did not differ from those at baseline in either group. CONCLUSIONS: The significant increase of NOx in half of the women receiving HRT suggests that only responders experience the cardioprotective effects of HRT.
Danuta Czarnecka; Kalina Kawecka-Jaszcz; Agnieszka Olszanecka; Aldona Dembińska-Kieć; Małgorzata Malczewska-Malec; Anna Zdzienicka; Ibeth Guevara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  10     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-22     Completed Date:  2004-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR55-61     Citation Subset:  IM    
1st Cardiac Department, Jagiellonian University Medical College, Kopernika 17, 31-501 Cracow, Poland.
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MeSH Terms
Administration, Cutaneous
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects,  physiology
Blood Pressure Monitoring, Ambulatory
Cholesterol, LDL / blood
Drug Combinations
Endothelium, Vascular / drug effects*,  physiology
Estradiol / administration & dosage,  blood,  pharmacology*
Follicle Stimulating Hormone / blood
Follow-Up Studies
Hormone Replacement Therapy*
Hypertension / drug therapy,  physiopathology*
Middle Aged
Nitric Oxide / blood
Nitrites / blood
Norethindrone / administration & dosage,  pharmacology*
Postmenopause / drug effects,  physiology*
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Cholesterol, LDL; 0/Drug Combinations; 0/Nitrites; 10102-43-9/Nitric Oxide; 50-28-2/Estradiol; 68-22-4/Norethindrone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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