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The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds-a randomized study.
MedLine Citation:
PMID:  22092836     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Malignant wounds (MWs) occur in 5-10% of all cancer patients. Malodor and exudation are the most common side effects. The aim was to determine the influence of honey-coated compared with silver-coated bandages on treatment of MWs. Patients were randomly selected to enter either group A (honey-coated bandages) or group B (silver-coated bandages). Parameters were the following: wound size, cleanliness, malodor, exudation, and wound pain. Digital photographs, visual analog scales (VAS), and wound morphology registration were used for measurement at baseline and following the 4-week intervention. Sixty-nine patients with MWs and advanced cancer, aged 47-90 (median 65.6), were included. No statistically significant difference was noted between the groups with respect to wound size, degree of cleanliness, exudation, malodor, and wound pain. There was a median decrease in wound size of 15 cm(2) and 8 cm(2) in group A and B, respectively (p = 0.63). Based on post-intervention pooled data from the groups, improvement was seen in 62% of the participants with respect to wound size and in 58% (n = 69) with respect to cleanliness. The VAS score for malodor (p = 0.007) and exudation (p < 0.0001) improved significantly post-intervention. Patients with reduced wound size had a median survival time of 387 days compared with 134 days in patients with no wound reduction (p = 0.003). The use of honey-coated and silver-coated bandages improved the outcome of MWs. No differences were found between the two regimens. Both types of bandages are recommended for use by patients with MWs containing tumor debris and necrosis.
Authors:
Betina Lund-Nielsen; Lis Adamsen; Hans Jørn Kolmos; Mikael Rørth; Anders Tolver; Finn Gottrup
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Publication Detail:
Type:  Journal Article     Date:  2011-10-13
Journal Detail:
Title:  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society     Volume:  19     ISSN:  1524-475X     ISO Abbreviation:  Wound Repair Regen     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9310939     Medline TA:  Wound Repair Regen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  664-70     Citation Subset:  IM    
Copyright Information:
© 2011 by the Wound Healing Society.
Affiliation:
The University Hospitals Center for Nursing and Care Research, Copenhagen, Denmark.
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