Document Detail


The effect of highly active antiretroviral therapy on outcome of central nervous system herpesviruses infection in Cuban human immunodeficiency virus-infected individuals.
MedLine Citation:
PMID:  17994429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the rapid progress in the development of highly active antiretroviral therapy (HAART), the observed patterns in human immunodeficiency virus (HIV) encephalitis has changed, allowing herpesvirus (HV) infection to be controlled. HAART was first administered to HIV patients in Cuba in 2001. Consequently with the aim of investigate the behavior of the HVs causing neurological disorders in this population in the post-HAART era, the authors perform a clinical evaluation by a multiplex nested polymerase chain reaction (PCR) assay for simultaneous detection of human HVs--herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), and Epstein-Barr virus (EBV). The authors studied 241 samples of cerebrospinal fluid (CSF) received at the Sexually Transmitted Diseases Laboratory between 2001 and 2005 inclusive. Of the 241 CSF studied, 10.4% resulted positive for HV infections. Of these, 92% of patients were acquired immunodeficiency syndrome (AIDS) individuals at the C3 stage. CMV (44%), EBV (28%), and dual-HV (16%) infections were the most important agents identified. The principal clinical manifestations were fever, headache, vomiting, and focal abnormalities; the latter being associated with an increased risk of death. A statistically significant result was observed when central nervous system (CNS) disease evolution was compared between patients who were under HAART against those who were not, before they developed encephalitis. It was therefore concluded that it is more likely that HIV individuals receiving HAART have a better recovery of CNS infections than those who are not receiving it.
Authors:
Pedro Ariel Martínez; René Díaz; Daniel González; Lisset Oropesa; Ruby González; Lissette Pérez; Jenniffer Viera; Vivian Kourí
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurovirology     Volume:  13     ISSN:  1355-0284     ISO Abbreviation:  J. Neurovirol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508123     Medline TA:  J Neurovirol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  446-51     Citation Subset:  IM    
Affiliation:
Virology Department, Institute of Tropical Medicine Pedro Kourí (IPK), Marianao 13, Ciudad Habana, Cuba.
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MeSH Terms
Descriptor/Qualifier:
Antiretroviral Therapy, Highly Active*
Central Nervous System Diseases / drug therapy*,  epidemiology,  virology*
Cuba / epidemiology
Cytomegalovirus Infections / drug therapy
DNA, Viral / genetics,  isolation & purification
Herpesviridae Infections / drug therapy*,  epidemiology,  genetics
Herpesvirus 1, Human
Herpesvirus 2, Human
Herpesvirus 6, Human
Humans
Odds Ratio
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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