| The effect of high temperature on alveolar macrophage counts in bronchoalveolar lavage fluid of F344 rats. | |
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MedLine Citation:
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PMID: 12451712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of high temperature on the number of alveolar macrophages (AMs) in bronchoalveolar lavage (BAL) fluid in rats, F344 rats were housed in environment chambers at 23 degrees C, 30 degrees C or 35 degrees C for up to 14 days. The number of AMs in the BAL fluid was significantly decreased in rats housed at 35 degrees C on days 7 and 14, compared to the control group housed at 23 degrees C. The total protein content and lactate dehydrogenase activity did not change at high temperatures in BAL supernatant, indicating that there was no increase in alveolar/capillary barrier permeability or lung cellular injury. The results might suggest that high temperature (35 degrees C) affects the pulmonary defense mechanism. |
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Authors:
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Shoji Yamamoto; Katsunori Sato |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental animals / Japanese Association for Laboratory Animal Science Volume: 51 ISSN: 1341-1357 ISO Abbreviation: Exp. Anim. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2003-05-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9604830 Medline TA: Exp Anim Country: Japan |
Other Details:
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Languages: eng Pagination: 505-8 Citation Subset: IM |
Affiliation:
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Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / cytology*, immunology* Cell Count Cell Movement Environmental Exposure / adverse effects* Hot Temperature / adverse effects* Macrophages, Alveolar / immunology* Male Monocytes Rats Rats, Inbred F344 Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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