| The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review. | |
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MedLine Citation:
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PMID: 20831550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients. |
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Authors:
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K Tewthanom; S Janwitayanujit; K Totemchockcyakarn; D Panomvana Na Ayudhya |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of clinical pharmacy and therapeutics Volume: 35 ISSN: 1365-2710 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
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Languages: eng Pagination: 483-5 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy, Silpakorn University, Thailand. karunrat@email.pharm.su.ac.th |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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administration & dosage*,
therapeutic use Antioxidants / administration & dosage*, therapeutic use Female Glutathione / blood Humans Lupus Nephritis / drug therapy* Malondialdehyde / blood Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 542-78-9/Malondialdehyde; 616-91-1/Acetylcysteine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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