Document Detail


The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review.
MedLine Citation:
PMID:  20831550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients.
Authors:
K Tewthanom; S Janwitayanujit; K Totemchockcyakarn; D Panomvana Na Ayudhya
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  35     ISSN:  1365-2710     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  483-5     Citation Subset:  IM    
Affiliation:
Faculty of Pharmacy, Silpakorn University, Thailand. karunrat@email.pharm.su.ac.th
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / administration & dosage*,  therapeutic use
Antioxidants / administration & dosage*,  therapeutic use
Female
Glutathione / blood
Humans
Lupus Nephritis / drug therapy*
Malondialdehyde / blood
Middle Aged
Chemical
Reg. No./Substance:
0/Antioxidants; 542-78-9/Malondialdehyde; 616-91-1/Acetylcysteine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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