| The effect of heparin versus citrate on blood echogenicity in vitro: the role of platelet and platelet-neutrophil aggregates. | |
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MedLine Citation:
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PMID: 1481287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is no consensus among investigators regarding which anticoagulant to use when studying the causes of in vitro blood echogenicity, despite the fact that heparin and calcium-chelating anticoagulants may have disparate effects due to their differing effects on platelets. This study quantitated the echogenicity of heparinized blood compared to citrated blood and found that it was greater in heparinized blood than in citrated blood when paired samples from the same donor, drawn at the same time were compared. By microscopic examination of the blood, this difference appeared to be due to the formation of platelet and platelet-neutrophil aggregates in the heparinized blood. This hypothesis was tested by comparing the echogenicity of heparinized blood to that of heparinized blood following platelet and white cell depletion. The results showed that taking away platelets and white cells virtually eliminated the echogenicity of heparinized blood; the impact of this result is discussed in the context of in vivo spontaneous contrast. |
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Authors:
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C Mahony; J Ferguson |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 18 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 1992 |
Date Detail:
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Created Date: 1993-02-11 Completed Date: 1993-02-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 851-9 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, University of Kentucky, Lexington 40506-0070. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / pharmacology Blood / drug effects, ultrasonography* Citrates / pharmacology Dogs Heparin / pharmacology Leukocytes Neutrophils Platelet Aggregation Video Recording |
| Grant Support | |
ID/Acronym/Agency:
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HL 38904/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Citrates; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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