Document Detail

The effect of heparin on endothelial stability.
MedLine Citation:
PMID:  6463964     Owner:  NLM     Status:  MEDLINE    
Heparin in ultra low doses had a stabilizing effect on endothelial lining in rats. This effect was demonstrated as prevention of increases in counts of circulating endothelial cells after a standard intravenous citrate injection. The same effect of heparin was observed even with other provoking agents /adrenaline, hypotonic saline/. The duration of heparin effect was very prolonged, a 50% effect having been observed 5 hours after the administration. Subcutaneous heparin was effective only in relatively high doses and had a lower maximum effect compared with intravenous heparin.
J Hladovec
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  35     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-19     Completed Date:  1984-09-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
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MeSH Terms
Blood Cell Count
Blood Vessels / drug effects
Citrates / toxicity
Endothelium / drug effects*
Epinephrine / toxicity
Heparin / pharmacology*
Heparin Antagonists / pharmacology
Hypotonic Solutions / toxicity
Protamines / pharmacology
Vascular Diseases / chemically induced
Reg. No./Substance:
0/Citrates; 0/Heparin Antagonists; 0/Hypotonic Solutions; 0/Protamines; 51-43-4/Epinephrine; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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