Document Detail

The effect of hemodilution on experimental myocardial infarct size.
MedLine Citation:
PMID:  7389766     Owner:  NLM     Status:  MEDLINE    
Hemodilution is used frequently for patients undergoing elective coronary bypass surgery but relatively little is known about the effects of hemodilution on acute myocardial infarction. Left ventricular infarctions were planimetered after acute coronary occlusion in dogs treated with and without hemodilution. The control group was maintained at a normal hematocrit (40-45) while the intervention group was hemodiluted with 6% dextran in saline 30 min after left anterior descending coronary artery occlusion to a hematocrit less than 50% of control (20). Systemic arterial and left atrial pressure were maintained at control levels as were arterial pO2 and pH. Mean infarct size in the control group was 20.72 +/- 1.38% (SEM) of the left ventricle while the hemodiluted group had a mean infarct size of 18.80 +/- 2.11% of the left ventricle. Reduction of red cell mass to less than 50% of normal does not increase the size of myocardial infarction after acute coronary artery occlusion suggesting that oxygen supply to ischemic areas is maintained if systemic hypoxia is prevented.
W Y Tucker; J Bean; S Vandevanter; L H Cohn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  12     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Coronary Disease / physiopathology
Disease Models, Animal
Myocardial Infarction / pathology,  physiopathology*
Oxygen / blood
Reg. No./Substance:

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