Document Detail

The effect of hematin on bilirubin binding in bilirubin-enriched neonatal cord serum.
MedLine Citation:
PMID:  6538099     Owner:  NLM     Status:  MEDLINE    
It has been suggested that the serum of infants with ABO hemolytic disease contains hematin which might interfere with bilirubin binding to albumin, increasing the risk of kerincterus. Using the horseradish peroxidase assay, we investigated this possibility. Cord serum from healthy term infants was enriched with bilirubin to a bilirubin/albumin molar ratio of 0.6, and then varying amounts of hematin were added. Hematin had a significant adverse effect on bilirubin binding when present in half to equimolar ratios with bilirubin. This high concentration of hematin does not appear to be present in serum from infants with ABO hemolytic disease and no difference was seen when comparing the dilute and the undilute peroxidase assays. These data suggest that hematin can alter bilirubin binding in neonatal serum but is not os physiologic importance for infants with ABO-isoimmune hemolysis.
J J Kirk; D A Ritter; J D Kenny
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  45     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1984  
Date Detail:
Created Date:  1984-04-12     Completed Date:  1984-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
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MeSH Terms
Bilirubin / blood*
Erythroblastosis, Fetal / blood
Fetal Blood / metabolism*
Heme / analogs & derivatives*
Hemin / analysis,  pharmacology*
Infant, Newborn
Protein Binding
Serum Albumin / metabolism
Reg. No./Substance:
0/Serum Albumin; 14875-96-8/Heme; 16009-13-5/Hemin; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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