Document Detail

The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.
MedLine Citation:
PMID:  16439720     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Breathing supplemental oxygen reduces breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). Replacing nitrogen with helium reduces expiratory flow resistance and may improve lung emptying. Combining these treatments should be independently effective.
OBJECTIVES: Study the effect of changing oxygen or helium concentration in inspired gas during exercise in patients with stable COPD.
METHODS: In 82 patients (mean age, 69.7 yr; mean FEV(1), 42.6% predicted), we measured endurance shuttle walking distance, resting and exercise oxygen saturation, and end-exercise dyspnea (Borg scale) while patients breathed Heliox28 (72% He/28% O(2)), Heliox21 (79% He/21% O(2)), Oxygen28 (72% N(2)/28% O(2)), or medical air (79% N(2)/21% O(2)). Gases were administered using a randomized, blinded, crossover design via a face mask and an inspiratory demand valve.
RESULTS: Breathing Heliox28 increased walking distance (mean+/-SD, 147+/-150 m) and reduced Borg score (-1.28+/-1.30) more than any other gas mixture. Heliox21 significantly increased walking distance (99+/-101 m) and reduced dyspnea (Borg score, -0.76+/-0.77) compared with medical air. These changes were similar to those breathing Oxygen28. The effects of helium and oxygen in Heliox28 were independent. The increase in walking distance while breathing Heliox28 was inversely related to baseline FEV(1) breathing air.
CONCLUSION: Reducing inspired gas density can improve exercise performance in COPD as much as increasing inspired oxygen. These effects can be combined as Heliox28 and are most evident in patients with more severe airflow obstruction.
Elizabeth A Laude; Nicholas C Duffy; Chloe Baveystock; Beatriz Dougill; Michael J Campbell; Rod Lawson; Paul W Jones; Peter M Calverley
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-01-26
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  173     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-07     Completed Date:  2006-05-16     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  865-70     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Cross-Over Studies
Exercise Tolerance / physiology*
Follow-Up Studies
Forced Expiratory Volume / physiology
Helium / therapeutic use*
Middle Aged
Oxygen Inhalation Therapy / methods*
Pulmonary Disease, Chronic Obstructive / physiopathology,  therapy*
Treatment Outcome
Walking / physiology
Reg. No./Substance:
Comment In:
Am J Respir Crit Care Med. 2006 Apr 15;173(8):825-6   [PMID:  16601127 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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