Document Detail


The effect of heavy metals (lead, manganese, mercury) on the concentration of free amino acids in the liver of rats.
MedLine Citation:
PMID:  6933936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors report their experimental data from a several years long study of the influence of Lead (Pb), Manganese (Mn), and Mercury (Hg) upon the free amino acid concentrations in the liver of rats. Comparing the effects of the metals investigated they established that the disorders caused by Pb and Mn become more serious with time after poisoning, while Hg shows early influence and changes. The concentration of the sulfur-containing amino acids (methionine and cysteine) decreases considerably under the influence of Pb and Mn. Mercury tends to produce an increase of the cysteine content, whilst methionine, after an initial elevation, gradually decreases to values similar to those of the controls.
Authors:
L Halatcheva; P Nikolova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement     Volume:  4     ISSN:  0171-9750     ISO Abbreviation:  Arch. Toxicol. Suppl.     Publication Date:  1980  
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802567     Medline TA:  Arch Toxicol Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  355-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Lead Poisoning / metabolism*
Liver / drug effects,  metabolism*
Manganese Poisoning*
Mercury Poisoning / metabolism*
Rats
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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