| The effect of heartburn and acid reflux on the severity of nausea and vomiting of pregnancy. | |
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MedLine Citation:
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PMID: 19373420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Heartburn (HB) and acid reflux (RF) in the nonpregnant population can cause nausea and vomiting; therefore, it is plausible that in women with nausea and vomiting of pregnancy (NVP), HB/RF may increase the severity of symptoms. OBJECTIVE: To determine whether HB/RF during pregnancy contribute to increased severity of NVP. METHODS: A prospectively collected cohort of women who were experiencing NVP and HB, RF or both (n=194) was studied. The Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scale and its Well-being scale was used to compare the severity of the study cohort's symptoms. This cohort was compared with a group of women experiencing NVP but no HB/RF (n=188). Multiple linear regression was used to control for the effects of confounding factors. RESULTS: Women with HB/RF reported higher PUQE scores (9.6+/-2.6) compared with controls (8.9+/-2.6) (P=0.02). Similarly, Well-being scores for women experiencing HB/RF were lower (4.3+/-2.1) compared with controls (4.9+/-2.0) (P=0.01). Multiple linear regression analysis demonstrated that increased PUQE scores (P=0.003) and decreased Well-being scores (P=0.005) were due to the presence of HB/RF as opposed to confounding factors such as pre-existing gastrointestinal conditions/symptoms, hyperemesis gravidarum in previous pregnancies and comorbidities. CONCLUSION: The present cohort study is the first to demonstrate that HB/RF are associated with increased severity of NVP. Managing HB/RF may improve the severity of NVP. |
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Authors:
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Simerpal Kaur Gill; Caroline Maltepe; Gideon Koren |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of gastroenterology = Journal canadien de gastroenterologie Volume: 23 ISSN: 0835-7900 ISO Abbreviation: Can. J. Gastroenterol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-17 Completed Date: 2009-06-12 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 8807867 Medline TA: Can J Gastroenterol Country: Canada |
Other Details:
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Languages: eng Pagination: 270-2 Citation Subset: IM |
Affiliation:
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The Motherisk Program, The Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Causality Comorbidity Female Gastroesophageal Reflux / diagnosis, epidemiology* Heartburn / diagnosis, epidemiology* Humans Morning Sickness / diagnosis, epidemiology* Ontario / epidemiology Pregnancy Prospective Studies Quality of Life Questionnaires Severity of Illness Index |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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