Document Detail


The effect of hardness of food on amygdalar histamine release in rats.
MedLine Citation:
PMID:  19961837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When animals eat food, the oral cavity receives a variety of sensory information from food. The hardness of food, which elicits somatic sensation, is thought to affect feeding behavior, however, the details of neuronal mechanism are unclear. The histaminergic system is known to be involved in feeding behavior, and our previous studies indicated that gustatory information activates the histaminergic system, and that palatability of tastants influences its activity. From these findings, we hypothesized that the hardness of food may affect the histaminergic system. Thus, in the present study, we examined the effect of the hardness of food on histamine release in the central nucleus of amygdala when rats consumed either of two types of pellets composed of similar ingredients but having different degrees of hardness: hard and soft pellets. Histamine release was significantly increased in the rat fed with hard pellets. By contrast, histamine release was not enhanced in soft pellets-fed rats. There were no significant differences between the hard and soft pellet intakes during the experimental period. When rats acquired a conditioned aversion to soft pellets, histamine release was increased during feeding, in sharp contrast to no change of histamine release pattern seen during unconditioned soft pellet intake. These observations indicate that the amygdalar histaminergic system is modulated by oral somatic sensation from food, and by palatability of food texture.
Authors:
Tomoko Ishizuka; Noritaka Sako; Tomotaka Murotani; Aya Morimoto; Atsushi Yamatodani; Kiyoshi Ohura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-02
Journal Detail:
Title:  Brain research     Volume:  1313     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier B.V. All rights reserved.
Affiliation:
Department of Pharmacology, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 573-1121, Japan. ishizuka@cc.osaka-dent.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Amygdala / physiology*
Animals
Avoidance Learning
Catheterization
Conditioning, Classical
Eating / physiology*
Feeding Behavior / physiology
Food*
Hardness
Histamine Release*
Male
Microdialysis
Perception / physiology*
Physical Stimulation
Rats
Rats, Wistar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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