Document Detail


The effect of guanethidine treatment of testicular blood flow and testosterone production in rats.
MedLine Citation:
PMID:  2347398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Testicular blood flow was measured by means of Xenon-133 clearance in control rats and rats treated with guanethidine for 3 weeks. Plasma and testis testosterone concentrations were also measured, and the effect of hCG-treatment was examined. No difference in testicular blood flow between the control group and the guanethidine-treated group was found. However, in guanethidine-treated rats, plasma and testis testosterone concentrations after hCG-treatment were significantly decreased. The results may indicate that adrenergic nerves are involved in the regulation of Leydig cell function.
Authors:
J E Damber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  46     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  486-7     Citation Subset:  IM    
Affiliation:
Department of Urology and Andrology, University of Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Fibers / drug effects,  physiology
Animals
Chorionic Gonadotropin / diagnostic use
Guanethidine / pharmacology*
Male
Rats
Rats, Inbred Strains
Regional Blood Flow / drug effects
Testis / blood supply*,  innervation,  metabolism
Testosterone / biosynthesis*,  blood
Xenon Radioisotopes / diagnostic use
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Xenon Radioisotopes; 55-65-2/Guanethidine; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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