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The effect of growth hormone treatment or physical training on motor performance in Prader-Willi syndrome: A systematic review.
MedLine Citation:
PMID:  22652271     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
REUS, L., L.A. van Vlimmeren, J.B. Staal, B.J. Otten and M.W.G. Nijhuis-van der Sanden. Effect of growth hormone treatment or physical training on motor performance in Prader-Willi syndrome: A systematic review. NEUROSCI BIOBEHAV REV .(.) XXX-XXX, 20… - Although motor problems in Prader-Willi syndrome (PWS) are prominent in infants, and continue into childhood and adulthood, there is little insight into the factors important for clinical management. The literature was reviewed to: 1) provide an overview of the characteristics and prevalence of motor problems; and 2) evaluate the effects of growth hormone (GH) treatment and physical training on motor performance. A systematic search revealed 34 papers: 13 on motor performance; 12 on GH treatment; and nine on physical training. In infants, motor development is 30-57% of the normal reference values, and children and adults also have significant problems in skill acquisition, muscle force, cardiovascular fitness, and activity level. GH treatment positively influenced motor performance in infants, children, and adults, although not all studies demonstrated an effect. All studies on physical training demonstrated beneficial effects in PWS patients. We suggest a combination of GH treatment and physical training to be started as soon as possible, especially in infants, to improve motor development as this will positively influence general development.
Authors:
Linda Reus; Leo A van Vlimmeren; J Bart Staal; Barto J Otten; Maria W G Nijhuis-van der Sanden
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-28
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  -     ISSN:  1873-7528     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Radboud University Nijmegen Medical Centre, Department of Rehabilitation, Pediatric Physical Therapy, Nijmegen, The Netherlands; Radboud University Medical Centre, Scientific Institute for Quality of Healthcare, Nijmegen, The Netherlands.
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