Document Detail

The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs.
MedLine Citation:
PMID:  19271111     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the effect of growth hormone releasing peptide (GHRP)-2, a synthetic ligand for the growth hormone secretagogue receptor, on upper gastrointestinal motility and food intake. METHODS: Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum. GHRP-2 (0.5-10 microg/kg) was administered intravenously in neurally intact dogs in the interdigestive state and after feeding. To study the mechanism of GHRP-2-induced inhibition on postprandial contractions, various antagonists were administered intravenously prior to GHRP-2. The effect of GHRP-2 on postprandial contractions was also studied in dogs with vagotomy. GHRP-2 was also administered immediately before feeding in each group, and its effect on food intake was assessed. RESULTS: GHRP-2 did not evoke gastrointestinal contractions in the interdigestive state. GHRP-2 induced contractile inhibition continuing for 2-3 min in neurally intact dogs and dogs with vagotomy. This inhibitory effect was reversed by the alpha- and alpha(2)-blockers. GHRP-2 increased food intake in neurally intact dogs, but not in dogs with vagotomy. CONCLUSIONS: These results indicate that in the upper gut GHRP-2 inhibits postprandial contractions via alpha(2)-receptors on the enteric nervous system, whereas an intact vagal nerve is necessary for a GHRP-2-induced increase in food intake.
Katsuyoshi Kudoh; Chikashi Shibata; Yuji Funayama; Kouhei Fukushima; Tatsuya Ueno; Keiichi Hayashi; Akio Inui; Cyril Y Bowers; Iwao Sasaki
Publication Detail:
Type:  Journal Article     Date:  2009-03-07
Journal Detail:
Title:  Journal of gastroenterology     Volume:  44     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-10     Completed Date:  2009-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  297-304     Citation Subset:  IM    
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
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MeSH Terms
Dose-Response Relationship, Drug
Duodenum / drug effects,  metabolism
Eating / drug effects*
Enteric Nervous System / drug effects,  metabolism
Gastrointestinal Motility / drug effects*
Jejunum / drug effects,  metabolism
Muscle Contraction / drug effects
Oligopeptides / administration & dosage,  pharmacology*
Postprandial Period
Pylorus / surgery
Receptors, Adrenergic, alpha-2 / drug effects*,  metabolism
Receptors, Ghrelin / agonists
Stomach / drug effects,  metabolism
Reg. No./Substance:
0/Oligopeptides; 0/Receptors, Adrenergic, alpha-2; 0/Receptors, Ghrelin; 0/growth hormone-releasing peptide-2

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