| The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs. | |
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MedLine Citation:
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PMID: 19271111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to evaluate the effect of growth hormone releasing peptide (GHRP)-2, a synthetic ligand for the growth hormone secretagogue receptor, on upper gastrointestinal motility and food intake. METHODS: Five neurally intact dogs and five dogs with vagotomy and pyloroplasty were equipped with strain gauge force transducers on the stomach, duodenum and jejunum. GHRP-2 (0.5-10 microg/kg) was administered intravenously in neurally intact dogs in the interdigestive state and after feeding. To study the mechanism of GHRP-2-induced inhibition on postprandial contractions, various antagonists were administered intravenously prior to GHRP-2. The effect of GHRP-2 on postprandial contractions was also studied in dogs with vagotomy. GHRP-2 was also administered immediately before feeding in each group, and its effect on food intake was assessed. RESULTS: GHRP-2 did not evoke gastrointestinal contractions in the interdigestive state. GHRP-2 induced contractile inhibition continuing for 2-3 min in neurally intact dogs and dogs with vagotomy. This inhibitory effect was reversed by the alpha- and alpha(2)-blockers. GHRP-2 increased food intake in neurally intact dogs, but not in dogs with vagotomy. CONCLUSIONS: These results indicate that in the upper gut GHRP-2 inhibits postprandial contractions via alpha(2)-receptors on the enteric nervous system, whereas an intact vagal nerve is necessary for a GHRP-2-induced increase in food intake. |
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Authors:
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Katsuyoshi Kudoh; Chikashi Shibata; Yuji Funayama; Kouhei Fukushima; Tatsuya Ueno; Keiichi Hayashi; Akio Inui; Cyril Y Bowers; Iwao Sasaki |
Publication Detail:
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Type: Journal Article Date: 2009-03-07 |
Journal Detail:
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Title: Journal of gastroenterology Volume: 44 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-10 Completed Date: 2009-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
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Languages: eng Pagination: 297-304 Citation Subset: IM |
Affiliation:
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Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Dose-Response Relationship, Drug Duodenum / drug effects, metabolism Eating / drug effects* Enteric Nervous System / drug effects, metabolism Gastrointestinal Motility / drug effects* Jejunum / drug effects, metabolism Muscle Contraction / drug effects Oligopeptides / administration & dosage, pharmacology* Postprandial Period Pylorus / surgery Receptors, Adrenergic, alpha-2 / drug effects*, metabolism Receptors, Ghrelin / agonists Stomach / drug effects, metabolism Vagotomy |
| Chemical | |
Reg. No./Substance:
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0/Oligopeptides; 0/Receptors, Adrenergic, alpha-2; 0/Receptors, Ghrelin; 0/growth hormone-releasing peptide-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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