Document Detail

The effect of growth hormone on nutritional markers in enterally fed immobilized trauma patients.
MedLine Citation:
PMID:  7658599     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Earlier clinical studies have demonstrated improved nitrogen balance in nonstressed patients receiving hypocaloric feedings and growth hormone (GH). This study investigates the effect of GH on nitrogen balance, on serum protein concentrations, and on other indices of nutrition when combined with enteral feeding in immobilized patients after closed-head injury or spinal cord injury. METHODS: Sixteen patients who tolerated enteral feedings and remained nonseptic were randomized to receive either placebo or 0.2 mg/kg recombinant human GH for 7 to 13 days. Nitrogen balances were collected daily, and serum proteins were measured at study entrance and exit. RESULTS: GH treatment resulted in higher GH and insulin-like growth factor-1 concentrations but did not improve nitrogen balance. GH treatment also resulted in increased transferrin and serum albumin levels and total lymphocyte count during the study period. CONCLUSIONS: Adjuvant recombinant human GH has no effect on nitrogen balance in highly stressed, totally immobilized patients after head or spinal cord injury, but it significantly enhances constitutive serum protein concentrations and other indices of nutritional repletion.
S W Behrman; K A Kudsk; R O Brown; K L Vehe; S L Wojtysiak
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  19     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1995 Jan-Feb
Date Detail:
Created Date:  1995-10-05     Completed Date:  1995-10-05     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM; S    
Department of Surgery, University of Tennessee at Memphis 38163, USA.
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MeSH Terms
Biological Markers / analysis
Enteral Nutrition*
Growth Hormone / blood,  therapeutic use*
Head Injuries, Closed / therapy*
Insulin-Like Growth Factor I / metabolism
Lymphocyte Count
Middle Aged
Nitrogen / metabolism
Recombinant Proteins / therapeutic use
Serum Albumin / metabolism
Spinal Cord Injuries / therapy*
Transferrin / metabolism
Reg. No./Substance:
0/Biological Markers; 0/Recombinant Proteins; 0/Serum Albumin; 11096-37-0/Transferrin; 67763-96-6/Insulin-Like Growth Factor I; 7727-37-9/Nitrogen; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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