| The effect of grape-seed extract on 24 h energy intake in humans. | |
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MedLine Citation:
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PMID: 15042136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Since grape-seed extract has been shown to stimulate lipolysis in vitro and reduce food intake in rats, we assessed the efficacy of grape-seed extract with respect to energy intake (EI) and satiety. DESIGN: In a randomized, placebo-controlled, double-blind, cross-over study, 51 subjects (age 18-65 y, body mass index 22-30 kg/m2) ate an ad libitum lunch and dinner twice in the University Restaurant for 3 days. Standard breakfasts and snacks were provided. Supplements were taken 30-60 min prior to each meal. RESULTS: In the total study population, no difference in 24 h EI was found between the grape-seed extract and placebo. However, in the subgroup of subjects (n=23) with an energy requirement > or =the median of 7.5 MJ/day, EI was reduced by 4% (DeltaEI 352.1 kJ/24 h, P=0.05) after grape-seed extract compared to placebo treatment. Meanwhile, there were no significant differences in macronutrient composition, attitude towards eating, satiety, mood or tolerance. CONCLUSIONS: Grape seed reduced 24 h EI, with on average 4% in subjects who had an energy requirement > or =7.5 MJ/day, without further effects on satiety, mood or tolerance. These findings suggest that grape seed could be effective in reducing 24 h EI in normal to overweight dietary unrestrained subjects, and could, therefore, play a significant role in body-weight management. |
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Authors:
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N Vogels; I M T Nijs; M S Westerterp-Plantenga |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 58 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-25 Completed Date: 2004-07-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 667-73 Citation Subset: IM |
Affiliation:
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Maastricht University, Human Biology, Maastricht, The Netherlands. N.Vogels@HB.Unimaas.NL |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anthropometry Cross-Over Studies Diet* Double-Blind Method Energy Intake / drug effects* Feeding Behavior Female Humans Male Middle Aged Plant Extracts / administration & dosage, pharmacology* Satiation / drug effects Seeds* Vitis* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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