| The effect of graded hypoxia on the embryonic chick heart. | |
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MedLine Citation:
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PMID: 4082074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Embryonic ventricular function in the chick was measured in response to graded levels of hypoxia. Myocardial contractility, as measured by cinephotoanalysis and expressed as shortening fraction, was significantly depressed after 1 hour of moderate hypoxia (6% O2) and after 5 hours of milder (16% O2 and 11% O2) levels of hypoxia (P less than .05). Microscopy confirmed associated myocyte damage with cell death noted after 5 hours of moderate hypoxic stress. Heart rate change was not related to the severity of hypoxia. The greatest level of tachycardia was noted with conditions of mildest hypoxia (16% O2). The data confirm that cardiac contractility, as measured by shortening fraction, is depressed on exposure to hypoxia, with impairment of function related to the severity of the hypoxic conditions. |
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Authors:
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R N Ruckman; G C Rosenquist; D A Rademaker; D E Morse; P R Getson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Teratology Volume: 32 ISSN: 0040-3709 ISO Abbreviation: Teratology Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-02-07 Completed Date: 1986-02-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0153257 Medline TA: Teratology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 463-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / pathology, physiopathology* Cardiac Volume Cell Nucleus / ultrastructure Chick Embryo Heart / embryology* Heart Rate Microscopy, Electron Motion Pictures as Topic Myocardial Contraction Myocardium / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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