Document Detail


The effect of gonadal hormones and gender on anxiety and emotional learning.
MedLine Citation:
PMID:  16904674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disorders of anxiety and fear dysregulation are highly prevalent. These disorders affect women approximately 2 times more than they affect men, occur predominately during a woman's reproductive years, and are especially prevalent at times of hormonal flux. This implies that gender differences and sex steroids play a key role in the regulation of anxiety and fear. However, the underlying mechanism by which these factors regulate emotional states in either sex is still largely unknown. This review discusses animal studies describing sex-differences in and gonadal steroid effects on affect and emotional learning. The effects of gonadal hormones on the modulation of anxiety, with particular emphasis on progesterone's ability to reduce the responsiveness of female rats to corticotropin releasing factor and the sex-specific effect of testosterone in the reduction of anxiety in male rats, is discussed. In addition, gonadal hormone and gender modulation of emotional learning is considered and preliminary data are presented showing that estrogen (E2) disrupts fear learning in female rats, probably through the antagonistic effect of ERalpha and ERbeta activation.
Authors:
Donna J Toufexis; Karyn M Myers; Michael Davis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2006-08-14
Journal Detail:
Title:  Hormones and behavior     Volume:  50     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-09-05     Completed Date:  2006-11-22     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-49     Citation Subset:  IM    
Affiliation:
Emory University, Department of Psychiatry, Yerkes National Primate Center, 954 Gatewood Drive NE, Atlanta, GA 30329, USA. dtoufex@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / epidemiology,  physiopathology*,  psychology
Arginine Vasopressin / physiology
Corticotropin-Releasing Hormone / physiology
Emotions / physiology*
Fear / physiology
Female
Gonadal Hormones / physiology*
Humans
Learning / physiology*
Light
Male
Pregnanolone / physiology
Septal Nuclei / physiopathology
Sex Characteristics*
Startle Reaction
Steroids / physiology
Grant Support
ID/Acronym/Agency:
MH 47840/MH/NIMH NIH HHS; MH 52384/MH/NIMH NIH HHS; MH 58922/MH/NIMH NIH HHS; MH 59906/MH/NIMH NIH HHS; RR00165/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Gonadal Hormones; 0/Steroids; 113-79-1/Arginine Vasopressin; 128-20-1/Pregnanolone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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