| The effect of glycopyrrolate (Robinul) on the lower oesophageal sphincter. | |
| | |
MedLine Citation:
|
PMID: 638828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Regurgitation and inhalation of acid gastric content, with resultant chemical pneumonitis, remains a common cause of death during anaesthesia. The effects of intravenous glycopyrrolate 0.3 mg on the lower oesophageal sphincter tone was studied in normal human subjects. Glycopyrrolate decreased lower oesophageal sphincter pressure by 0.88 kPa (p less than 0.005). This finding is of clinical importance in the pre-operative preparation of patients presenting for emergency surgery. A drug which decreases lower oesophageal sphincter tone would presumably increase the hazard of gastro-oesophageal reflux and pulmonary aspiration of acid gastric content. |
| | |
Authors:
|
J G Brock-Utne; J Rubin; S Welman; G E Dimopoulos; M G Moshal; J W Downing |
Related Documents
:
|
3799898 - Distinction of lower esophageal sphincter strength from sphincter competence. 3364858 - The effect of nalbuphine on the common bile duct pressure. 20924368 - Weak peristalsis in esophageal pressure topography: classification and association with... 8055728 - Discrepancies in anal manometric pressure measurement--important or inconsequential? 6085668 - Colloid and crystalloid fluid resuscitation. 3799898 - Distinction of lower esophageal sphincter strength from sphincter competence. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Canadian Anaesthetists' Society journal Volume: 25 ISSN: 0008-2856 ISO Abbreviation: Can Anaesth Soc J Publication Date: 1978 Mar |
Date Detail:
|
Created Date: 1978-06-28 Completed Date: 1978-06-28 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0371163 Medline TA: Can Anaesth Soc J Country: CANADA |
Other Details:
|
Languages: eng Pagination: 144-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Esophagogastric Junction / drug effects*, physiology Glycopyrrolate / pharmacology* Humans Pressure Pyrrolidines / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Pyrrolidines; 596-51-0/Glycopyrrolate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Late complications of prolonged tracheal intubation.
Next Document: Asymptomatic diaphragmatic defect--a post-operative problem.