| The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia. | |
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MedLine Citation:
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PMID: 15117599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The goal of this study is to evaluate the effect of glyceryl trinitrate (GTN) in the management of hypertension in women with preeclampsia, eclampsia, and HELLP syndrome. STUDY DESIGN: Fifty five women with preeclampsia, eclampsia, and HELLP syndrome administered GTN infusion for the management of hypertension were studied. Demographic, clinical, and perinatal outcome findings were collected for analyses. We recorded initial and maintenance doses of GTN, and duration of its use in prepartum and postpartum periods. We collected systolic and diastolic blood pressures (BPs) at admission and before the administration of GTN infusion. During the GTN infusion, we calculated average diastolic and systolic blood pressures 6 hours apart on the first day, 12 hours apart on the second day, and 24 hours apart on the third day. RESULTS: Of 55 women, 24 with severe preeclampsia, 16 with HELLP syndrome, and 15 with eclampsia were included in this study. In severe preeclampsia group, GTN infusion significantly reduced systolic and diastolic BPs beginning from the second quarter and third quarter, respectively, of first day (p < 0.05). In the HELLP syndrome group, GTN infusion significantly decreased systolic and diastolic blood pressures beginning from the third quarter and second quarter, respectively, of the first day (p < 0.05). In the eclampsia group, GTN infusion significantly reduced systolic and diastolic blood pressures beginning from the third quarter and first quarter, respectively, of the first day (p < 0.05). CONCLUSION: In women with severe preeclampsia, eclampsia, and HELLP syndrome, infusion of GTN can be used as an alternative agent to well-known drugs and causes no significant adverse effect to the mother and fetus. |
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Authors:
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Ali Cetin; Nazan Yurtcu; Tevfik Guvenal; Ayse Gonca Imir; Bulent Duran; Meral Cetin |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 23 ISSN: 1064-1955 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2004 |
Date Detail:
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Created Date: 2004-04-30 Completed Date: 2004-09-30 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: United States |
Other Details:
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Languages: eng Pagination: 37-46 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey. cetin@ttnet.net.tr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartate Aminotransferases / blood Bilirubin / blood Biological Markers / blood Blood Platelets / metabolism Blood Pressure / drug effects Diastole / drug effects Eclampsia / drug therapy* Female HELLP Syndrome / drug therapy Humans Hypertension / drug therapy* Maternal Welfare Nitroglycerin / therapeutic use* Pre-Eclampsia / drug therapy Pregnancy Retrospective Studies Severity of Illness Index Systole / drug effects Tocolytic Agents / therapeutic use* Treatment Outcome Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tocolytic Agents; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 635-65-4/Bilirubin; EC 2.6.1.1/Aspartate Aminotransferases |
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