Document Detail


The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia.
MedLine Citation:
PMID:  15117599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The goal of this study is to evaluate the effect of glyceryl trinitrate (GTN) in the management of hypertension in women with preeclampsia, eclampsia, and HELLP syndrome.
STUDY DESIGN: Fifty five women with preeclampsia, eclampsia, and HELLP syndrome administered GTN infusion for the management of hypertension were studied. Demographic, clinical, and perinatal outcome findings were collected for analyses. We recorded initial and maintenance doses of GTN, and duration of its use in prepartum and postpartum periods. We collected systolic and diastolic blood pressures (BPs) at admission and before the administration of GTN infusion. During the GTN infusion, we calculated average diastolic and systolic blood pressures 6 hours apart on the first day, 12 hours apart on the second day, and 24 hours apart on the third day.
RESULTS: Of 55 women, 24 with severe preeclampsia, 16 with HELLP syndrome, and 15 with eclampsia were included in this study. In severe preeclampsia group, GTN infusion significantly reduced systolic and diastolic BPs beginning from the second quarter and third quarter, respectively, of first day (p < 0.05). In the HELLP syndrome group, GTN infusion significantly decreased systolic and diastolic blood pressures beginning from the third quarter and second quarter, respectively, of the first day (p < 0.05). In the eclampsia group, GTN infusion significantly reduced systolic and diastolic blood pressures beginning from the third quarter and first quarter, respectively, of the first day (p < 0.05).
CONCLUSION: In women with severe preeclampsia, eclampsia, and HELLP syndrome, infusion of GTN can be used as an alternative agent to well-known drugs and causes no significant adverse effect to the mother and fetus.
Authors:
Ali Cetin; Nazan Yurtcu; Tevfik Guvenal; Ayse Gonca Imir; Bulent Duran; Meral Cetin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  23     ISSN:  1064-1955     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-30     Completed Date:  2004-09-30     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspartate Aminotransferases / blood
Bilirubin / blood
Biological Markers / blood
Blood Platelets / metabolism
Blood Pressure / drug effects
Diastole / drug effects
Eclampsia / drug therapy*
Female
HELLP Syndrome / drug therapy
Humans
Hypertension / drug therapy*
Maternal Welfare
Nitroglycerin / therapeutic use*
Pre-Eclampsia / drug therapy
Pregnancy
Retrospective Studies
Severity of Illness Index
Systole / drug effects
Tocolytic Agents / therapeutic use*
Treatment Outcome
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Tocolytic Agents; 0/Vasodilator Agents; EC 2.6.1.1/Aspartate Aminotransferases; G59M7S0WS3/Nitroglycerin; RFM9X3LJ49/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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