Document Detail

The effect of glutamine supplementation on the function of neutrophils from exercised rats.
MedLine Citation:
PMID:  15617036     Owner:  NLM     Status:  MEDLINE    
In a recent publication, we showed the protective effect of glutamine on neutrophil apoptosis induced by acute exercise. The purpose of the present study was to examine the effect of a single bout of intensive exercise on rat neutrophil function and the possible effect of glutamine supplementation. An aqueous solution of glutamine was given by gavage (1 g per kg b.w.), 1 h before the exercise session. The exercise was carried out on a treadmill for 1 h at 85% VO2máx.. Neutrophils were obtained by intraperitoneal lavage with PBS. The following parameters were evaluated: phagocytosis capacity, production of nitric oxide and reactive oxygen metabolites, expression of iNOS, and expression of NADPH-oxidase components (p22phox, p47phox and gp91phox). One hour of exercise at 85% VO2max. induced no change in the phagocytosis capacity and reactive oxygen species production but decreased nitric oxide production. When rats received oral glutamine supplementation, the phagocytosis capacity was significantly increased, the decrease in nitric oxide production induced by exercise was abolished and production of reactive oxygen species was raised. Glutamine supplementation presents a significant effect on neutrophil function including changes induced by exercise.
Claudia Jacques Lagranha; Thais Martins de Lima; Sueli Moreno Senna; Sonia Quatelli Doi; Rui Curi; Tania Cristina Pithon-Curi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  23     ISSN:  0263-6484     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-02-28     Completed Date:  2005-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 John Wiley & Sons, Ltd.
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil.
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MeSH Terms
Glutamine / pharmacology*
Neutrophils / drug effects*,  physiology*
Nitric Oxide / metabolism
Nitric Oxide Synthase / biosynthesis
Nitric Oxide Synthase Type II
Oxygen Consumption
Phagocytosis / drug effects
Physical Conditioning, Animal*
Rats, Wistar
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Reactive Oxygen Species; 10102-43-9/Nitric Oxide; 56-85-9/Glutamine; EC Oxide Synthase; EC Oxide Synthase Type II; EC protein, rat

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