Document Detail

The effect of glutamine-enriched enteral nutrition on intestinal microflora in very low birth weight infants: a randomized controlled trial.
MedLine Citation:
PMID:  17499398     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: In a previous study, we have found that glutamine supplementation decreased the infection rate in very low birth weight (VLBW) infants. In this study, we investigated whether this beneficial effect originated from increased number of bifidobacteria and lactobacilli in the intestinal microflora of these infants. METHODS: In a randomized controlled trial, VLBW infants (gestational age <32 weeks and/or birth weight <1500g) received enteral glutamine supplementation (0.3g/kg/day) or isonitrogenous placebo supplementation between d3 and d30 of life. Faecal microflora was determined by fluorescent in situ hybridization <48h, at d7, d14 and d30 of life. RESULTS: In 43/52 (glutamine group) and 43/50 (control group) infants, > or = 2 samples were analyzed. Baseline characteristics were not different between groups. The prevalence of bifidobacteria, lactobacilli, Escheria coIi, streptococci and clostridia was not different between groups (p>0.05). In both groups, colonization with bifidobacteria was delayed, whereas potentially pathogenic bacteria such as E. coli, appeared rapidly after birth. Antibiotic treatment decreased the prevalence of all faecal bacteria (p<0.05). CONCLUSIONS: Decreased infectious morbidity in VLBW infants that received glutamine supplementation was not associated with alterations in the prevalence of bifidobacteria, lactobacilli, E. coIi, streptococci and clostridia. In general, colonization with health-promoting bacteria was delayed, whereas potentially pathogenic bacteria appeared rapidly after birth. Antibiotic treatment delayed the bacterial colonization.
Anemone van den Berg; Ruurd M van Elburg; Elisabeth A M Westerbeek; Esmeralda G M van der Linde; J Knol; Jos W R Twisk; Willem P F Fetter
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-05-11
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  26     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  430-9     Citation Subset:  IM    
Department of Paediatrics, Subdivision of Neonatology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands.
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MeSH Terms
Bifidobacterium / drug effects*,  growth & development
Colony Count, Microbial / methods
Double-Blind Method
Enteral Nutrition / methods*
Escherichia coli / drug effects,  growth & development
Feces / microbiology
Glutamine / administration & dosage*,  pharmacology
In Situ Hybridization, Fluorescence / methods
Infant, Newborn
Infant, Very Low Birth Weight* / growth & development
Intestines / microbiology*
Lactobacillus / drug effects*,  growth & development
Time Factors
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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