| The effect of glucose polymers on water removal and protein clearances during CAPD. | |
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MedLine Citation:
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PMID: 7692975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two selected groups of 5 continuous ambulatory peritoneal dialysis (CAPD) patients (3 female, 7 male), mean age 60 years, were studied twice with an interval of 4 weeks. The first study was done with glucose-containing dialysate and the second study with dialysate containing glucose polymers (Dextrin 7.5%) after they had been treated with this solution (night dwell) for 4 weeks. The patients collected night bags for 3 consecutive days during the tests. Protein clearances were determined for beta 2-microglobulin, albumin, IgG, fibronectin, and alpha 2-macroglobulin in both periods to examine the influence of crystalloid-induced convection versus "colloid"-induced convection. Group I normally used 1.50% glucose and was therefore considered to have a "high ultrafiltration";group II was the "low ultrafiltration" group because they needed 4.25% glucose dialysate. For their usual glucose solutions the net ultrafiltration was not different between both groups, but the clearance of beta 2-microglobulin was higher in group II:839 +/- 98 microL/min (group I) and 1135 +/- 131 microL/min (group II) (p = 0.08). For glucose polymers the net ultrafiltration increased in both groups, but this was more pronounced in group II: 657 +/- 104 mL (group I) and 918 +/- 85 mL (group II) (p = 0.06). Also, the clearance of beta 2-microglobulin increased with the glucose polymer solution: 1268 +/- 94 microL/min (for glucose polymer) and 987 +/- 85 microL/min (for glucose) (p < 0.05), but the clearances of the larger serum proteins remained unaffected.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A L Imholz; C B Brown; G C Koomen; L Arisz; R T Krediet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis Volume: 9 ISSN: 1197-8554 ISO Abbreviation: Adv Perit Dial Publication Date: 1993 |
Date Detail:
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Created Date: 1993-12-10 Completed Date: 1993-12-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9104803 Medline TA: Adv Perit Dial Country: CANADA |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: IM |
Affiliation:
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Department of Medicine, Academic Medical Center, Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Albumins / metabolism Blood Proteins / metabolism* Dextrins / administration & dosage, pharmacology* Dialysis Solutions* Female Fibronectins / metabolism Glucose Humans Immunoglobulin G / metabolism Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* Ultrafiltration alpha-Macroglobulins / metabolism beta 2-Microglobulin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Blood Proteins; 0/Dextrins; 0/Dialysis Solutions; 0/Fibronectins; 0/Immunoglobulin G; 0/alpha-Macroglobulins; 0/beta 2-Microglobulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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