Document Detail

The effect of glucose polymers on water removal and protein clearances during CAPD.
MedLine Citation:
PMID:  7692975     Owner:  NLM     Status:  MEDLINE    
Two selected groups of 5 continuous ambulatory peritoneal dialysis (CAPD) patients (3 female, 7 male), mean age 60 years, were studied twice with an interval of 4 weeks. The first study was done with glucose-containing dialysate and the second study with dialysate containing glucose polymers (Dextrin 7.5%) after they had been treated with this solution (night dwell) for 4 weeks. The patients collected night bags for 3 consecutive days during the tests. Protein clearances were determined for beta 2-microglobulin, albumin, IgG, fibronectin, and alpha 2-macroglobulin in both periods to examine the influence of crystalloid-induced convection versus "colloid"-induced convection. Group I normally used 1.50% glucose and was therefore considered to have a "high ultrafiltration";group II was the "low ultrafiltration" group because they needed 4.25% glucose dialysate. For their usual glucose solutions the net ultrafiltration was not different between both groups, but the clearance of beta 2-microglobulin was higher in group II:839 +/- 98 microL/min (group I) and 1135 +/- 131 microL/min (group II) (p = 0.08). For glucose polymers the net ultrafiltration increased in both groups, but this was more pronounced in group II: 657 +/- 104 mL (group I) and 918 +/- 85 mL (group II) (p = 0.06). Also, the clearance of beta 2-microglobulin increased with the glucose polymer solution: 1268 +/- 94 microL/min (for glucose polymer) and 987 +/- 85 microL/min (for glucose) (p < 0.05), but the clearances of the larger serum proteins remained unaffected.(ABSTRACT TRUNCATED AT 250 WORDS)
A L Imholz; C B Brown; G C Koomen; L Arisz; R T Krediet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  9     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-10     Completed Date:  1993-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Department of Medicine, Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Albumins / metabolism
Blood Proteins / metabolism*
Dextrins / administration & dosage,  pharmacology*
Dialysis Solutions*
Fibronectins / metabolism
Immunoglobulin G / metabolism
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
alpha-Macroglobulins / metabolism
beta 2-Microglobulin / metabolism
Reg. No./Substance:
0/Albumins; 0/Blood Proteins; 0/Dextrins; 0/Dialysis Solutions; 0/Fibronectins; 0/Immunoglobulin G; 0/alpha-Macroglobulins; 0/beta 2-Microglobulin; 50-99-7/Glucose

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