| The effect of glucagon on urine amylase in various animal species. | |
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MedLine Citation:
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PMID: 6197880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucagon effects on the kidney include increased water, creatinine, and amylase clearance. We have compared these effects in several laboratory animal species. Although every species responded to glucagon, 1 mg iv, by some alteration in renal function there were differences in the degree and direction of the changes. Glucagon caused an increase in amylase clearance in four of the six species studied and an increase in creatinine clearance in four. An increase in urine flow tended to occur in all species. An increased amylase clearance is a feature of acute pancreatitis, and raised glucagon levels have been found during attacks. It is possible that the two are causally related. In the experimental situation, timing of urine collections and species differences were found to be of critical importance in exploring this possibility. |
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Authors:
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B S Goodwin; S A Cucinell; J O'Brien |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 79 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-02-20 Completed Date: 1984-02-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 46-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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blood,
urine* Animals Cats Creatinine / blood, urine Dogs Female Glucagon / metabolism, pharmacology* Kidney / metabolism Macaca mulatta Male Metabolic Clearance Rate Rabbits Rats Rats, Inbred Strains Species Specificity Specimen Handling Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine; 9007-92-5/Glucagon; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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