Document Detail

The effect of glucagon, dibutyrylic cyclic AMP and theophylline on bile production in the cat.
MedLine Citation:
PMID:  223377     Owner:  NLM     Status:  MEDLINE    
The effect of glucagon, dibutyrylic cyclic AMP and theophylline on bile production and liver metabolism was studied in fasting, chloralose anesthetized cats. After 45 min infusion of glucagon (0.1 mug/kg/min) total bile flow started to increase and finally reached a level 32% above control bile flow. The rise in flow was accompanied by a parallel increase in the biliary clearance of erythritol and the rate of biliary excretion of inorganic ions, whereas the bile acid excretion remained constant. Glucagon therefore appears to stimulate selectively the bile acid-independent canalicular production of bile. In contrast to the delayed action on bile production, glucagon caused an immediate change in liver metabolism as judged from the elimination rate of ethanol and the rise in plasma glucose concentration. Dibutyrylic cyclic AMP or theorphylline also caused similar immediate changes in liver metabolism but neither substance influenced bile production or the biliary excretion of electrolytes or bile acids. It thus appears that glucagon choleresis in the cat is either independent of cAMP release or that an increase in intracellular cAMP is not in itself sufficient to influence bile secretion. The results also seem to exclude that an increase in insulin production induced by hyperglycemia, or hemodynamic changes in the liver, can explain glucagon choleresis.
J A Larsen; N Krarup; Thomsen Oø
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  106     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  23-7     Citation Subset:  IM    
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MeSH Terms
Bile* / secretion
Blood Glucose / analysis
Bucladesine / pharmacology*
Cholagogues and Choleretics
Ethanol / blood
Glucagon / pharmacology*
Liver / metabolism*
Theophylline / pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/Cholagogues and Choleretics; 362-74-3/Bucladesine; 58-55-9/Theophylline; 64-17-5/Ethanol; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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