| The effect of gizzerosine, a recently discovered compound in overheated fish meal, on the gastric acid secretion in chicken. | |
| | |
MedLine Citation:
|
PMID: 3991416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of gizzerosine [2-amino-9-(4-imidazolyl)-7-azanonanoic acid], which causes gizzard erosion in chicks, on gastric acid secretion was studied in young chicks. Three-day-old broiler chicks given a diet containing synthetic DL-gizzerosine showed severe symptoms of gizzard erosion after 7 days. The pH of the gastric and duodenal contents of these chicks was lower than that of the control chicks, demonstrating that acid secretion was enhanced in gizzerosine-fed chicks. The pH of gastric contents was lower and the amount of total gastric acid was higher in 1-day fasted chicks injected with gizzerosine intravenously than in those injected with physiological saline solution. The intramuscular injection of cimetidine, H2-receptor antagonist of histamine, blocked the stimulation of acid secretion by gizzerosine and by histamine. Cimetidine added in feed also prevented gizzard erosion, which was induced by feeding overheated mackerel meal. The results showed that gizzard erosion developed after oral or intravenous administration of gizzerosine is caused at least in part by the enhanced gastric acid secretion. Furthermore, it was suggested that gizzerosine acts on H2-receptor of histamine and stimulates the gastric acid secretion in broiler chicks. |
| | |
Authors:
|
T Masumura; M Sugahara; T Noguchi; K Mori; H Naito |
Related Documents
:
|
6140926 - N,n-dimethyl-10-(3-quinuclidinyl)-2-phenothiazine sulfonamide (lm 24056): mode of actio... 11935026 - Bile acid secreted by male sea lamprey that acts as a sex pheromone. 3927746 - Deoxycorticosterone-stimulated bicarbonate secretion in rabbit cortical collecting duct... 5843616 - Histamine synthesis and gastric secretion after portacaval shunt. 6140926 - N,n-dimethyl-10-(3-quinuclidinyl)-2-phenothiazine sulfonamide (lm 24056): mode of actio... 8387826 - The continuing development of gastric acid pump inhibitors. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Poultry science Volume: 64 ISSN: 0032-5791 ISO Abbreviation: Poult. Sci. Publication Date: 1985 Feb |
Date Detail:
|
Created Date: 1985-05-28 Completed Date: 1985-05-28 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0401150 Medline TA: Poult Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 356-61 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Chickens / physiology* Cimetidine / pharmacology Fish Flour* Fish Products* Fishes Gastric Acid / secretion* Gastric Acidity Determination / veterinary Gizzard / drug effects Histamine / pharmacology Hot Temperature Hydrogen-Ion Concentration Imidazoles / pharmacology* Receptors, Histamine H2 / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Imidazoles; 0/Receptors, Histamine H2; 51-45-6/Histamine; 51481-61-9/Cimetidine; 89238-78-8/gizzerosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of the antimycoplasma activity of two commercially available tylosin premixes.
Next Document: A comparison of methods for organ-weight data adjustment in chicks.