Document Detail

The effect of gestational age on the outcome of second-trimester termination of pregnancies for foetal abnormalities.
MedLine Citation:
PMID:  18509869     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the effect of gestational age on the outcome of second-trimester termination of pregnancies for foetal abnormalities. METHOD: A retrospective study was conducted on 280 pregnancies terminated for foetal abnormalities in the second trimester using vaginal misoprostol. The gestational age at termination was divided into three groups: 13-16 weeks, 17-20 weeks and 21-23 weeks. The likelihood of (1) abortion within 24 h of commencement of misoprostol, (2) incomplete abortion and (3) experiencing significant side effects was compared among these three gestational groups after adjusting for maternal age, parity and body mass index (BMI). RESULTS: Compared to termination after 20 weeks, pregnancy termination for foetal abnormality before 17 weeks of gestation was associated with higher chance of incomplete abortion (OR 2.2, 95% CI 1.07-4.61, p = 0.032) and lower chance of experiencing significant side effects (OR 0.11, 95% CI 0.01-0.91, p = 0.041). CONCLUSION: Women undergoing pregnancy termination for foetal abnormalities in the early second trimester should be informed of possible higher chance of incomplete abortion.
T K Lo; W L Lau; F K Lai; H Lam; H Y Tse; W C Leung; R K H Chin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  28     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  508-11     Citation Subset:  IM    
Prenatal Diagnosis and Counselling Centre, Department of Obstetrics and Gynaecology, Kwong Wah Hospital, Hong Kong SAR, China.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage
Abortion, Incomplete / etiology
Abortion, Induced*
Administration, Intravaginal
Congenital Abnormalities*
Fetal Diseases*
Gestational Age*
Misoprostol / administration & dosage
Pregnancy Trimester, Second*
Retrospective Studies
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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