| The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma. | |
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MedLine Citation:
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PMID: 15104212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are many potential sources of reactive oxidants around the time of birth and pre-term infants are considered to be particularly vulnerable to oxidative injury. To gain insight into these processes, we have measured biomarkers of lipid and protein oxidation in umbilical cord plasma and related concentrations to mode of delivery and gestational age. Protein carbonyls were measured by ELISA and malondialdehyde (MDA) by HPLC after reaction with thiobarbituric acid, for 54 pre-term (< or = 36 weeks gestational age) and 43 term infants. Protein carbonyls were significantly lower in pre-term (median for < 32 weeks gestational age 0.048nmol/mg protein) than in term infants (0.105 nmol/mg, p = 0.004), and were unrelated to mode of delivery. In contrast, MDA concentrations were higher in the very pre-term (<32 weeks gestation) group (2.47 compared with 1.83 microM for term infants, p < 0.0001). MDA concentrations were higher in infants who were born with labour compared with elective caesarean section. Pre-eclampsia in the mother was associated with higher cord blood MDA concentrations. The MDA results are consistent with other studies of this marker and could be interpreted as indicating increased oxidative stress associated with prematurity and labour. However, the lower protein carbonyls in pre-term infants would lead to an opposite interpretation. More information is needed on the source and fate of these and other biomarkers before drawing strong conclusions on how they reflect oxidative stress in this and other clinical situations. |
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Authors:
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Tessa J Mocatta; Christine C Winterbourn; Terrie E Inder; Brian A Darlow |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 38 ISSN: 1071-5762 ISO Abbreviation: Free Radic. Res. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-04-23 Completed Date: 2004-09-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 185-91 Citation Subset: IM |
Affiliation:
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Department of Pathology, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Birth Weight Blood Proteins / metabolism* Chromatography, High Pressure Liquid Enzyme-Linked Immunosorbent Assay Female Fetal Blood / metabolism* Gestational Age* Humans Infant, Newborn Infant, Premature / blood*, metabolism Labor, Obstetric* Lipid Peroxidation* Malondialdehyde / metabolism Oxidation-Reduction Oxidative Stress Pregnancy Pregnancy Complications / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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