| Effect of gastric acid suppression with pantoprazole on the efficacy of sevelamer hydrochloride as a phosphate binder in haemodialysis patients: a pilot study. | |
| | |
MedLine Citation:
|
PMID: 22329674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sevelamer hydrochloride (HCL) is thought to require an appropriately acidic environment in order to bind gastrointestinal phosphate. Changes in gastric acidity with acid suppressants may therefore alter the efficacy of sevelamer HCL. Given the widespread use of acid suppression therapy in chronic kidney disease patients, there is potential for a common significant drug interaction to occur. This pilot study evaluated the in vivo effect of gastric acid suppression with pantoprazole on the efficacy of sevelamer HCL as a phosphate binder in maintenance haemodialysis patients. The study protocol was a cross-over, double-blinded, randomized, placebo-controlled trial in 10 haemodialysis patients randomly assigned to pantoprazole 40 mg daily or placebo for two consecutive 6-week periods. Serum phosphate was not significantly altered during pantoprazole compared with placebo treatment (1.61 ± 0.45 mmol/L vs 1.76 ± 0.42 mmol/L, P = 0.204). There were no differences in serum calcium, parathyroid hormone and bicarbonate. This pilot study demonstrates preliminary in vivo evidence for no effect of gastric acid suppression on the effectiveness of sevelamer HCL. Our results are limited by small sample size and therefore, larger experimental studies should be conducted. Although our study did not find a significant drug interaction, given the high prevalence of acid suppressant use in dialysis patients, physicians should be aware of the potential influence of acid suppression on the efficacy of phosphate binders and regularly assess the clinical need for acid suppression therapy. |
| | |
Authors:
|
Beryl Lai; Matthew J Cervelli |
Related Documents
:
|
1512254 - 4-oxatetradecanoic acid is fungicidal for cryptococcus neoformans and inhibits replicat... 811564 - Enterotoxigenic intestinal bacteria in tropical sprue. iv. effect of linoleic acid on g... 3729394 - Effects of dissolved oxygen concentration on biodegradation of 2,4-dichlorophenoxyaceti... 8626324 - Acid shock induction of rpos is mediated by the mouse virulence gene mvia of salmonella... 3884584 - Analytical methods for determining ascorbic acid in biological samples, food products, ... 20209524 - Enantioselective organocatalytic addition of oxazolones to 1,1-bis(phenylsulfonyl)ethyl... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Nephrology (Carlton, Vic.) Volume: 17 ISSN: 1440-1797 ISO Abbreviation: Nephrology (Carlton) Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-18 Completed Date: 2012-08-13 Revised Date: 2013-06-04 |
Medline Journal Info:
|
Nlm Unique ID: 9615568 Medline TA: Nephrology (Carlton) Country: Australia |
Other Details:
|
Languages: eng Pagination: 402-6 Citation Subset: IM |
Copyright Information:
|
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology. |
Affiliation:
|
Department of Pharmacy, The Queen Elizabeth Hospital School of Pharmacy, University of South Australia, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
2-Pyridinylmethylsulfinylbenzimidazoles
/
therapeutic use* Aged Biological Markers / blood Chelating Agents / therapeutic use* Cross-Over Studies Double-Blind Method Female Gastric Acid / secretion* Gastric Mucosa / drug effects*, secretion Humans Hydrogen-Ion Concentration Hyperphosphatemia / blood, drug therapy*, etiology Kidney Diseases / blood, complications, therapy* Male Middle Aged Phosphates / blood Pilot Projects Placebos Polyamines / therapeutic use* Proton Pump Inhibitors / therapeutic use* Renal Dialysis* / adverse effects South Australia Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Biological Markers; 0/Chelating Agents; 0/Phosphates; 0/Placebos; 0/Polyamines; 0/Proton Pump Inhibitors; 182683-00-7/sevelamer; D8TST4O562/pantoprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Circumferential wires as a supplement to intramedullary nailing in unstable trochanteric hip fractur...
Next Document: Evaluation of retinal nerve fibre layer thickness and visual evoked potentials in optic neuritis ass...