| The effect of gamma-hydroxybutyrate on mouse striatal tyramine, dopamine and homovanillic acid. | |
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MedLine Citation:
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PMID: 7066598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 The concentrations of p- and m-tyramine, dopamine and homovanillic acid were measured in the mouse striatum following the subcutaneous injection of gamma-hydroxybutyrate; their control levels were 19.8, 6.3, 9600 and 1130 ng/g respectively. 2 The administration of 500-1000 mg/kg of gamma-hydroxybutyrate produced a reduction in p-tyramine that lasted at least 8 h. m-Tyramine and dopamine were significantly increased for at least 4 h. The levels of homovanillic acid were increased at 1 and 2 h after drug administration. 3 There experiments strongly suggest that the increases in dopamine turnover produced by gamma-hydroxybutyrate caused reciprocal changes in striatal tyramine that are similar to those produced by drug or treatment that increase dopamine turnover and tyrosine hydroxylase activity. |
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Authors:
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A V Juorio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 75 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-06-21 Completed Date: 1982-06-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 447-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Striatum / drug effects, metabolism* Dopamine / metabolism* Homovanillic Acid / metabolism Hydroxybutyrates / pharmacology* Isomerism Male Mice Sodium Oxybate Tyramine / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxybutyrates; 306-08-1/Homovanillic Acid; 502-85-2/Sodium Oxybate; 51-67-2/Tyramine; 588-05-6/3-tyramine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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