| The effect of furosemide and bumetanide on cerebrospinal fluid formation. | |
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MedLine Citation:
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PMID: 6791768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complete inhibition of carbonic anhydrase maximally reduces CSF flow 40-60%. We have confirmed that CSF flow in rabbits may be maximally decreased in this way by acetazolamide 30 mg/kg i.v., but have found only about 20% reduction from control after furosemide at 50 mg/kg i.v. This effect of furosemide is consistent with specific but partial inhibition of carbonic anhydrase of choroid plexus (and perhaps other sites of CSF secretion) based on the affinity of furosemide for carbonic anhydrase. Bumetanide, with 7 times lower affinity for carbonic anhydrase and 14-40 times higher inhibition of renal electrolyte transport processes than furosemide, did not decrease CSF flow. |
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Authors:
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B P Vogh; M R Langham |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 221 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1981-11-24 Completed Date: 1981-11-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 171-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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pharmacology Animals Bumetanide / pharmacology* Carbonic Anhydrases / metabolism Cerebrospinal Fluid / drug effects, physiology* Choroid Plexus / enzymology Diuretics / pharmacology* Dogs Erythrocytes / enzymology Furosemide / blood, pharmacology* Humans Kinetics Protein Binding Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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EY 02227/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 28395-03-1/Bumetanide; 54-31-9/Furosemide; 59-66-5/Acetazolamide; EC 4.2.1.1/Carbonic Anhydrases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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